Pathogenesis, Diagnosis and Treatment of Endocrine Cancers

Dear Colleagues, 

Recent advances in genome, epigenome, and transcriptome analyses have greatly expanded our understanding of cancers arising in the endocrine glands, including the thyroid, parathyroid, adrenal, and neuroendocrine glands. This knowledge has paved the way for precision and personalized treatments for both sporadic and hereditary forms of endocrine cancers. 

In the field of thyroidology, preoperative molecular markers have proven valuable for the accurate detection of malignancy in indeterminate nodules, reducing the need for unnecessary surgical interventions. Molecular and pathway-based analyses now allow for better prognostic classification and more reliable prediction of treatment response, especially for multikinase inhibitors. Meanwhile, genetic dissection of adrenal cancers and paragangliomas has uncovered key roles for IGF and WNT signaling pathways in tumorigenesis. Despite these advances, therapeutic progress for advanced and metastatic disease remains limited. 

In this Special Issue, we aim to focus on the molecular mechanisms underlying endocrine cancers and their translation into targeted therapeutic approaches. We welcome contributions spanning basic science, preclinical research, and translational studies, with the aim of advancing both understanding and management of endocrine malignancies.

Dr. Rajeev Parameswaran
Guest Editor

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