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Biomedicines
Special Issues
Colorectal Adenocarcinoma: From Pathophysiology to Novel Therapeutic Approaches
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Colorectal Adenocarcinoma: From Pathophysiology to Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3084

Special Issue Editors

Dr. Bong-hyeon Kye

E-Mail Website
Guest Editor
Department of Surgery, St. Vincent’s Hospital, The Catholic University of Korea, 93-1, Jungbu-daero, Paldal-gu, Suwon-si 16247, Gyeonggi-do, Korea
Interests: colorectal cancer; low anterior resection syndrome; minimally invasive surgery; microbiota in colon and rectum
Dr. Ri Na Yoo

E-Mail Website
Guest Editor
Division of Colorectal Surgery, Department of Surgery, St. Vincent Hospital, The Catholic University of Korea 93-6, Ji-dong, Paldal-gu, Suwon 442-723, Gyeonggi-do, Korea
Interests: colorectal cancer; low anterior resection syndrome; minimally invasive surgery; microbiota in colon and rectum

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) is the third most diagnosed cancer and a leading cause of cancer-related death worldwide. For the past several decades, significant progress in its molecular pathogenesis has led to precise treatment and patient management.

Recently, knowledge regarding pathogenesis of colorectal cancer has grown, but it is still limited. Understanding the underlying molecular mechanisms of CRC is essential to improve early diagnosis and patient-tailored treatment. Furthermore, the unique clinicopathologic features and risk factors of CRC are not well defined yet. There is an urgent need to clarify clinical features and risk factors different from another GI tract malignancy to implement specific screening and management strategies. Especially, in this Special Issue, we would like to deal with the management of relatively rare conditions of CRC such as obstructive colon and rectal cancer, lateral pelvic lymph node metastasis from rectal cancer, early-onset (young age) CRC, and quality of life in CRC survivorships.

In this Special Issue, review articles with a focus on the molecular biology, biomarkers, clinicopathologic characteristics, risk factors, and treatment strategies are invited.

Dr. Bong-hyeon Kye
Dr. Ri Na Yoo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstructive colon and rectal cancer
  • lateral pelvic lymph node
  • early-onset colorectal cancer
  • CRC survivorship

Published Papers (2 papers)

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Research

16 pages, 4937 KiB  
Article
The Safe Values of Quantitative Perfusion Parameters of ICG Angiography Based on Tissue Oxygenation of Hyperspectral Imaging for Laparoscopic Colorectal Surgery: A Prospective Observational Study
by Gyung Mo Son, Armaan M. Nazir, Mi Sook Yun, In Young Lee, Sun Bin Im, Jae Yeong Kwak, Sang-Ho Park, Kwang-Ryul Baek and Ines Gockel
Biomedicines 2023, 11(7), 2029; https://doi.org/10.3390/biomedicines11072029 - 19 Jul 2023
Cited by 1 | Viewed by 1277
Abstract
Background: Safe values for quantitative perfusion parameters of indocyanine green (ICG) angiography have not been fully defined, and interpretation remains at the surgeon’s discretion. This prospective observational study aimed to establish the safe values for the quantitative perfusion parameters by comparing tissue oxygenation [...] Read more.
Background: Safe values for quantitative perfusion parameters of indocyanine green (ICG) angiography have not been fully defined, and interpretation remains at the surgeon’s discretion. This prospective observational study aimed to establish the safe values for the quantitative perfusion parameters by comparing tissue oxygenation levels from HSI images in laparoscopic colorectal surgery. Methods: ICG angiography was performed using a laparoscopic near-infrared (NIR) camera system with ICG diluted in 10 mL of distilled water. For quantitative perfusion parameters, the changes in fluorescence intensity with perfusion times were analyzed to plot a time–fluorescence intensity graph. To assess real-time tissue oxygen saturation (StO2) in the colon, the TIVITA® Tissue System was utilized for hyperspectral imaging (HSI) acquisition. The StO2 levels were compared with the quantitative perfusion parameters derived from ICG angiography at corresponding points to define the safe range of ICG parameters reflecting good tissue oxygenation. Results: In the regression analysis, T1/2MAX, TMAX, slope, and NIR perfusion index were correlated with tissue oxygen saturation. Using this regression model, the cutoff values of quantitative perfusion parameters were calculated as T1/2MAX ≤ 10 s, TMAX ≤ 30 s, slope ≥ 5, and NIR perfusion index ≥50, which best reflected colon StO2 higher than 60%. Diagnostic values were analyzed to predict colon StO2 of 60% or more, and the ICG perfusion parameters T1/2MAX, TMAX, and perfusion TR showed high sensitivity values of 97% or more, indicating their ability to correctly identify cases with acceptable StO2. Conclusion: The safe values for quantitative perfusion parameters derived from ICG angiography were T1/2MAX ≤ 10 s and TMAX ≤ 30 s, which were associated with colon tissue oxygenation levels higher than 60% in the laparoscopic colorectal surgery. Full article
(This article belongs to the Special Issue Colorectal Adenocarcinoma: From Pathophysiology to Novel Therapeutic Approaches)
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11 pages, 1564 KiB  
Article
Significance of Wnt/β-Catenin Signal Activation for Resistance to Neoadjuvant Chemoradiotherapy in Rectal Cancer
by Shoji Miyako, Takeru Matsuda, Yu-ichiro Koma, Takahiro Koide, Ryuichiro Sawada, Hiroshi Hasegawa, Kimihiro Yamashita, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Taro Oshikiri and Yoshihiro Kakeji
Biomedicines 2023, 11(1), 174; https://doi.org/10.3390/biomedicines11010174 - 10 Jan 2023
Cited by 2 | Viewed by 1311
Abstract
Although a therapeutic response to neoadjuvant chemoradiotherapy (NACRT) is important to improve oncological outcomes after surgery in patients with locally advanced rectal cancer, there is no reliable predictor for this. The Wnt/β-catenin signal is known to be crucial for the tumorigenesis of colorectal [...] Read more.
Although a therapeutic response to neoadjuvant chemoradiotherapy (NACRT) is important to improve oncological outcomes after surgery in patients with locally advanced rectal cancer, there is no reliable predictor for this. The Wnt/β-catenin signal is known to be crucial for the tumorigenesis of colorectal cancer. This study aimed to investigate the association of Wnt/β-catenin signal activation with a pathological response to NACRT. The immunohistochemical expression of nuclear and membranous β-catenin was analyzed in biopsy samples obtained from 60 patients with locally advanced rectal cancer who received curative surgery following NACRT. The association of Wnt/β-catenin signal activation with their clinical outcomes was investigated. Notably, the body mass index of these patients was significantly higher in the low nuclear β-catenin expression group. Moreover, patients in the high nuclear β-catenin expression group tended to have more advanced disease and a higher rate of positive vascular invasion than those in the low expression group. Furthermore, the rate of good histological responses was significantly higher in the low nuclear β-catenin expression group (72% vs. 37.1%, p < 0.01). Overall, relapse-free survival tended to be better in patients with low nuclear/high membranous β-catenin expression (n = 9) than in other individuals (n = 51) (p = 0.093 and p = 0.214, respectively). Activation of the Wnt/β-catenin signal pathway represented by nuclear β-catenin accumulation was significantly associated with a poor response to NACRT in patients with rectal cancer. Analysis of nuclear β-catenin accumulation before starting treatment might help predict the therapeutic response to NACRT. Full article
(This article belongs to the Special Issue Colorectal Adenocarcinoma: From Pathophysiology to Novel Therapeutic Approaches)
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