Roles of Extracellular Vesicles in the Complex Interaction Between Metabolic Disorder and Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 184
Special Issue Editor
Special Issue Information
Dear Colleagues,
Metabolic disorders, such as obesity, diabetes, and cardiovascular diseases, have been linked to the development and progression of tumors. Epidemiological studies have shown a strong correlation between metabolic abnormalities and the incidence of various types of cancer. For instance, obesity, particularly morbid obesity (with a body mass index ≥40 kg/m²), has been associated with an increased risk of developing certain cancers, such as liver, breast, and pancreatic cancer. Similarly, type 2 diabetes (T2D) has been linked to an elevated risk of cancer, with the strongest associations observed for liver, pancreatic, and endometrial cancers.
Extracellular vesicles (EVs), small membrane-bound vesicles released by cells, play a pivotal role in the intricate interplay between metabolic disorders and cancer. They serve as crucial vehicles for intercellular communication, carrying and transferring bioactive molecules such as proteins, lipids, metabolites, RNA, and DNA to recipient cells, thereby influencing their functions. They exacerbate metabolic disorders by conveying related signals and promote cancer growth and metastasis by delivering tumor-associated signals. EVs also serve as biomarkers and potential therapeutic carriers, offering new avenues for the prevention and treatment of these diseases. This Special Issue aims at understanding the mechanistic and therapeutic aspects of this crucial relationship in order to improve the prevention, diagnosis, and treatment of cancer.
Dr. Keyang Xu
Guest Editor
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Keywords
- extracellular vesicles
- metabolic disorders
- obesity
- diabetes
- cardiovascular diseases
- cancer
- mechanism
- diagnosis
- treatment
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