Special Issue "Alcohol and Opioid Addiction-Scope, Mechanisms and Treatment Strategies"

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (31 August 2018).

Special Issue Editor

Dr. Ashok K. Singh
E-Mail Website
Guest Editor
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA
Interests: nanoparticle synthesis; nanomedicine; nanotoxicology; alcoholism; withdrawal syndrome; inflammation; oxidative stress; puerarin; curcumin; neurotoxicity
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Special Issue Information

Dear Colleagues,

Alcohol and opioid (such as heroin, morphine, and prescription pain relievers) abuses are serious global problems affecting the health, social, and economic welfare of all societies. In the United States, approximately 15.1 million adults ages 18 and older suffer alcohol abuse disorder. This includes 9.8 million men and 5.3 million women. It is also estimated that between 26.4 to 36 million people abuse opioids worldwide, of which an estimated 2.1 million people reside in the United. A unique aspect of alcoholism and opioid addiction is their comorbidity. People addicted to opioids often abuse alcohol and, concomitantly, alcoholics are more susceptible to abusing recreational or prescription opioids. Alcohol, when taken with opioids, increases central nervous system depression, thus increasing the risk for overdose. According to a report from Food Drug Administration (FDA), alcohol was involved in (i) 18.5% of opioids and 27.2% of benzodiazepine drug abuse-related Emergency visits and (ii) 22.1% of OPR and 21.4% of benzodiazepine drug-related deaths. These findings substantiate the contention that alcohol plays a significant role in opioid abuse and vice versa. Although mechanisms underlying the alcohol-opioid comorbidity is not fully understood, alcohol and opioids both may activate opioid receptors, inhibit GABA and dopamine signaling, and activate glutamate receptors. An understanding of the precise mechanisms of alcoholism and opioid addiction will help develop interventions to reduce the abuse of alcohol and opioids alone and in combination. Therefore, the aim of this Special Issue is to publish manuscripts in different aspects of alcoholism and opioid addiction. In general, manuscripts related to the following topics are being solicited.

  • Global prevalence of alcoholism and opioid addiction
  • Multifaceted mechanisms of alcohol and opioid addictions.
  • Opioid-ethanol interaction: socio-psychological, mechanistic, addictive and clinical studies.
  • Metabolism, pharmacokinetics and pharmacodynamics of ethanol and opioids (external and/or internal peptides), alone or in combination.
  • Current and future therapeutic (pharmacological, genomic, genetic, nano-therapeutic and stem cell mediated therapy) strategies against alcoholism and opioid addiction.
  • Other topics related to addiction mechanisms and therapeutics.

Dr. Ashok K. Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Alcoholism
  • opioids
  • addiction
  • comorbidity
  • opioid-ethanol interaction
  • socio-psychology
  • pharmacotherapy
  • gene therapy
  • stem cells
  • brain mechanisms
  • pharmacokinetics

Published Papers (1 paper)

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Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid
Biomedicines 2019, 7(1), 16; https://doi.org/10.3390/biomedicines7010016 - 07 Mar 2019
Cited by 11 | Viewed by 4089
Millions of people around the world drink alcoholic beverages to cope with the stress of modern lifestyle. Although moderate alcohol drinking may have some relaxing and euphoric effects, uncontrolled drinking exacerbates the problems associated with alcohol abuse that are exploding in quantity and [...] Read more.
Millions of people around the world drink alcoholic beverages to cope with the stress of modern lifestyle. Although moderate alcohol drinking may have some relaxing and euphoric effects, uncontrolled drinking exacerbates the problems associated with alcohol abuse that are exploding in quantity and intensity in the United States and around the world. Recently, mixing of alcohol with other drugs of abuse (such as opioids, cocaine, methamphetamine, nicotine, cannabis, and γ-hydroxybutyric acid) and medications has become an emerging trend, exacerbating the public health concerns. Mixing of alcohol with other drugs may additively or synergistically augment the seriousness of the adverse effects such as the withdrawal symptoms, cardiovascular disorders, liver damage, reproductive abnormalities, and behavioral abnormalities. Despite the seriousness of the situation, possible mechanisms underlying the interactions is not yet understood. This has been one of the key hindrances in developing effective treatments. Therefore, the aim of this article is to review the consequences of alcohol’s interaction with other drugs and decipher the underlying mechanisms. Full article
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