Biomarkers of Traumatic Brain Injury

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 246

Special Issue Editors


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Guest Editor
1. Department of Neurosurgery, Medical School, University of Pecs, H-7623 Pecs, Hungary
2. Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, H-7624 Pecs, Hungary
3. ELKH-PTE Clinical Neuroscience MR Research Group, H-7623 Pecs, Hungary
Interests: traumatic brain injury (head injury); biomarkers; animal models; histopathological consequences; repetitive mild TBI; therapeutic (neuroprotective) interventions
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Neurosurgery, Medical School, University of Pecs, H-7623 Pecs, Hungary
2. Neurotrauma Research Group, Szentagothai Research Centre, University of Pecs, H-7624 Pecs, Hungary
3. ELKH-PTE Clinical Neuroscience MR Research Group, H-7623 Pecs, Hungary
Interests: traumatic brain injury (head injury); biomarkers; animal models; repetitive mild TBI; coagulopathy

Special Issue Information

Dear Colleagues,

According to the definition of the BEST (Biomarkers, EndpointS, and other Tools) Resource (created by the FDA-NIH Biomarker Working Group), a biomarker could be a defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or biological responses to an exposure or intervention, including therapeutic interventions. Biomarkers may include molecular, histologic, radiographic, or physiologic characteristics. Categories of biomarkers include: susceptibility/risk biomarker, diagnostic biomarker, monitoring biomarker, prognostic biomarker, predictive biomarker, response biomarker, safety biomarker.

With regard to the circulating protein biomarkers of traumatic brain injury (TBI), while some breakthroughs have recently been made in the field of diagnostic biomarkers (the implementation of the S100B protein to the Scandinavian guideline as a diagnostic tool for mild TBI and FDA clearance for the Banyan Brain Trauma Indicator Kit (GFAP + UCH-L1) for the diagnosis of mTBI in the USA) and recent studies have confirmed the prognostic power of the most commonly investigated biomarker molecules, there are still lots of uncertainties even regarding the exact diagnostic and/or prognostic capabilities of these few thus far relatively well-characterized/identified molecules.

From a broad perspective, there is still a clear unmet clinical need for efficient diagnostic, prognostic, monitoring, etc., biomarkers or biomarker combinations which could enhance the treatment as well as the long-term rehabilitation of TBI patients.

In light of this, our current Special Issue is open for the submission of any manuscripts which include clinical as well as experimental observations regarding biomarkers (primarily—but not restricted to—protein biomarkers) of traumatic brain injury.

Dr. Endre Czeiter
Dr. Krisztina Amrein
Guest Editors

Manuscript Submission Information

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Keywords

  • traumatic brain injury
  • head injury
  • biomarkers
  • diagnostic
  • prognostic
  • experimental
  • animal models
  • clinical trials

Published Papers

There is no accepted submissions to this special issue at this moment.
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