Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches, 2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 172

Special Issue Editor

Special Issue Information

Dear Colleagues,

Osteoarthritis (OA), the most common form of arthritis, is a leading cause of debilitating pain and disability, affecting more than 32 million people in the US. The prevalence and incidence of OA have been continuously increasing due to increases in lifespan and obesity.

This Special Issue aims to present evidence of the potential targets, therapeutic drugs, and nanoformulations, and their mechanisms in treating osteoarthritis and associated pain. We welcome original research and review papers focused on the mechanisms and therapeutic potential of phytochemicals, peptides, and synthetic nanoparticle-based formulations that are engaged in improving osteoarthritic pain in preclinical and clinical studies. Furthermore, we encourage studies using in vivo and in vitro models to explore the mechanisms of action and interactions of nanoformulations with the molecular mediators of oxidative/nitrosative stress caused by osteoarthritic pain conditions.

Specific topics covered by this Special Issue include:

  • Basic and applied osteoarthritic pain research.
  • Multidisciplinary osteoarthritic pain research.
  • Osteoarthritis and comorbidities.
  • Drug studies involve the treatment of osteoarthritis.
  • Genetics in osteoarthritis.
  • Molecular mechanisms of osteoarthritis and associated pain.

Dr. Gurjit Singh
Guest Editor

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Keywords

  • osteoarthritis
  • pain
  • cartilage degeneration
  • molecular pain pathway

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Research

16 pages, 2167 KiB  
Article
Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration
by Dawid Sobański, Małgorzata Sobańska, Rafał Staszkiewicz, Damian Strojny, Werner Dammermann, Paweł Gogol, Weronika Wieczorek-Olcha, Artur Chwalba and Beniamin Oskar Grabarek
Biomedicines 2025, 13(7), 1530; https://doi.org/10.3390/biomedicines13071530 (registering DOI) - 23 Jun 2025
Abstract
Background/Objectives: Degenerative spinal conditions, such as degenerative stenosis, have been linked to metabolic and lifestyle factors, including obesity, smoking, and diabetes. Glial cell line-derived neurotrophic factor (GDNF) plays a crucial role in neuroprotection, but its relationship with these risk factors remains unclear. [...] Read more.
Background/Objectives: Degenerative spinal conditions, such as degenerative stenosis, have been linked to metabolic and lifestyle factors, including obesity, smoking, and diabetes. Glial cell line-derived neurotrophic factor (GDNF) plays a crucial role in neuroprotection, but its relationship with these risk factors remains unclear. Methods: This study aims to evaluate the relationship between body mass index (BMI), smoking, diabetes, and GDNF levels in patients with degenerative spine conditions. We measured the GDNF levels in patients with degenerative stenosis and assessed the impact of BMI, smoking status, and the presence of diabetes. Comparisons were made using appropriate statistical analyses to determine the significance of these factors on GDNF levels. Results: A significant inverse relationship was observed between the BMI and GDNF levels (p < 0.01). Patients with a higher BMI exhibited lower GDNF concentrations. Additionally, patients who smoked or had diabetes showed significantly lower GDNF levels compared to non-smokers and those without diabetes (p = 0.03 and p = 0.02, respectively). These findings suggest that both metabolic and lifestyle factors are associated with decreased GDNF, which may accelerate neurodegenerative processes in the spine. Conclusions: Our study demonstrates that increased BMI, smoking, and diabetes are linked to reduced GDNF levels, potentially contributing to the progression of degenerative spine conditions such as stenosis. These findings highlight the need for targeted clinical interventions to manage these risk factors, aiming to preserve GDNF levels and slow the degenerative processes in the spine. Future research should explore therapeutic approaches to modulate GDNF in affected populations. Full article
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