Morphomolecular Characterization of Neoplastic and Pre-neoplastic Lesions in Solid Malignancies

Dear Colleagues,

Traditionally, morphological evaluation represented the conventional approach for diagnosing and classifying neoplastic and pre-neoplastic lesions. However, recent advancements in molecular biology techniques have deeply revolutionized our understanding of solid malignancies contributing to the investigation of genetic alterations, gene expression patterns, epigenetic modifications, and protein expression that drive tumor initiation, progression, and metastasis. This knowledge has opened up opportunities for the development of targeted therapies that specifically inhibit these pathways. Moreover, molecular profiling integrated with morphological analysis can significantly improve diagnostic accuracy, prognostic stratification, and tailored treatment strategies, leading to improved therapeutic outcomes and minimizing adverse effects.

In conclusion, the morphomolecular characterization of neoplastic and pre-neoplastic lesions in solid malignancies represents a multidisciplinary approach that combines traditional morphological analysis with cutting-edge molecular techniques. This integrated approach provides a comprehensive understanding of the complex landscape of tumors and holds great promise for improving diagnosis, prognosis, and treatment outcomes in the field of oncology. Continued research in this area will undoubtedly lead to further advancements and breakthroughs in our fight against cancer.

We especially welcome original translational research studies highlighting new findings in the abovementioned areas, and short communications of preliminary but significant experimental results. In addition, experts in the field will review the current diagnostic, therapeutic, and experimental models.

Dr. Giuseppe Nicolò Fanelli
Dr. Edoardo Francini
Dr. Pier Vitale Nuzzo
Dr. Cristian Scatena
Guest Editors

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• solid cancer
• molecular pathology
• histopathology
• diagnostic, prognostic, and predictive biomarkers