Genetic Research of Hearing Loss

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1344

Special Issue Editors


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Guest Editor
Department of Otolaryngology Head and Neck Surgery, School of Biological Science and Medical Engineering, Zhongda Hospital, Southeast University, Nanjing, China
Interests: gene therapy; inner ear drug delivery; hearing loss; vestibular disorders; inner ear surgery
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Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Interests: hereditary deafness; hearing loss; vertigo; cochlear development; auditory transduction; vestibular rehabilitation
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Guest Editor
The Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China
Interests: hearing; aminoglycoside; mitochondria
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Department of Clinical Science, Technology and Intervention, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
Interests: genetic hearing loss; gene/stem cell therapy; inner ear drug delivery; hearing loss; vestibular dysfunction
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Special Issue Information

Dear Colleagues,

Hearing loss is the most common sensory impairment in humans, and approximately 50% of childhood-onset sensorineural hearing loss is of genetic origin. 

Genetic hearing loss can be inherited in autosomal dominant, autosomal recessive, X-linked, or mitochondrial patterns, and it may affect the external or middle ear, the inner ear, the auditory nerve, or a combination of these auditory pathways. Among these, sensorineural hearing loss resulting from defects in the inner ear (cochlea) and/or neural auditory pathways is the most prevalent. Less commonly, genetic mutations may cause malformations of the external or middle ear.

This Special Issue of Biomedicines will focus on Genetic Research of Hearing Loss.

We are honored to invite researchers from all over the world to submit their original research articles, reviews, and other contributions to this Special Issue. We welcome significant and exciting new findings that advance the understanding of genetic hearing loss.

You may choose our Joint Special Issue in Journal of Otorhinolaryngology, Hearing and Balance Medicine.

Dr. Ling Lu
Dr. Jun Yang
Dr. Min-Xin Guan
Dr. Maoli Duan
Guest Editors

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Keywords

  • genetic
  • sensorineural hearing loss
  • inner ear drug delivery
  • gene therapy
  • genetic screening
  • hearing aids
  • cochlear implantation

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Published Papers (1 paper)

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Review

17 pages, 624 KB  
Review
Connexins in Acquired Hearing Loss: Expanding Research Perspectives
by Sihan Huang, Jingyi Zhu, Jifang Zhang, Tianyu Gong, Zhongyuan Fei, Penghui Chen, Shule Hou and Jun Yang
Biomedicines 2025, 13(12), 3109; https://doi.org/10.3390/biomedicines13123109 - 17 Dec 2025
Viewed by 941
Abstract
Connexins, as key players in intercellular communication in the inner ear, are vital for maintaining normal hearing function. While numerous studies have explored their role in congenital hereditary hearing loss, the underlying mechanisms and therapeutic potential of connexins in acquired hearing loss remain [...] Read more.
Connexins, as key players in intercellular communication in the inner ear, are vital for maintaining normal hearing function. While numerous studies have explored their role in congenital hereditary hearing loss, the underlying mechanisms and therapeutic potential of connexins in acquired hearing loss remain to be fully elucidated. This review summarizes recent advances in connexin research in the context of acquired hearing loss, with a focus on presbycusis, noise-induced, and drug-induced hearing loss, and delves into their pathophysiological roles. Through the analysis and organization of these research findings, the article aims to provide a theoretical basis and research direction for future connexin-targeted therapies for acquired hearing loss. Full article
(This article belongs to the Special Issue Genetic Research of Hearing Loss)
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