Molecular Mechanisms and Translational Research on Insulin Resistance
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 444
Special Issue Editor
Interests: toxicology; mycotoxins; epigenetics; DNA methylation; histone modifications; non-coding RNA; epitranscriptomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Insulin resistance lies at the core of numerous metabolic diseases, including type 2 diabetes mellitus, obesity, non-alcoholic fatty liver disease, and cardiovascular diseases, amongst others. Despite decades of research, the intricate molecular and epigenetic mechanisms underlying insulin resistance remain poorly understood, and effective targeted therapies are limited. With the prevalence of metabolic disorders rising globally, we need to deepen our understanding of the biological mechanisms driving insulin resistance and translate this knowledge into effective clinical strategies. This Special Issue will showcase current advances in molecular research and translational approaches related to insulin resistance.
Authors are invited to submit original research articles, reviews, and clinical studies that address, but are not limited to, the following themes:
- Disruptions in insulin signaling pathways and metabolic regulation;
- The role of epigenetics and epitranscriptomics in insulin resistance;
- The role of inflammatory pathways, oxidative stress, and mitochondrial dysfunction in insulin resistance;
- Identifying and validating novel biomarkers for insulin resistance;
- Emerging therapeutic interventions, including pharmacological approaches, for combatting insulin resistance.
Dr. Terisha Ghazi
Guest Editor
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Keywords
- insulin resistance
- type 2 diabetes mellitus
- metabolic syndrome
- insulin signaling
- inflammation
- oxidative stress
- mitochondrial dysfunction
- epigenetics
- epitranscriptomics (e.g., m6A RNA methylation)
- biomarkers
- translational medicine
- therapeutic targets
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