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Biomedicines
Special Issues
Acute Pancreatitis: Biology, Diagnosis and Therapy
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Acute Pancreatitis: Biology, Diagnosis and Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 5189

Special Issue Editor

Dr. Rajarshi Mukherjee

E-Mail Website
Guest Editor
1. Liverpool University Hospitals NHS Foundation Trust, Liverpool L9 9BY, UK
2. Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7BE, UK
Interests: inflammation; cell signaling; cell death; molecular cell biology; biomarker discovery; translational drug discovery

Special Issue Information

Dear Colleagues,

Acute pancreatitis has potentially devastating consequences and no targeted drug therapy at present. The disease has rising incidence rates worldwide and severe forms of the disease carry a significant burden of morbidity and mortality. Through sustained research endeavors, multiple critical pathogenic mechanisms have been identified that play a role in disease pathogenesis; however, none have been translated to positive clinical trial results yet. This Special Issue focuses on the latest developments in acute pancreatitis, including the identification of the most promising novel pathogenic mechanisms and putative drug targets, biomarker discovery, and the assessment of unique diagnostic and prognostic tests, alongside the evaluation of original therapeutic approaches in preclinical settings. The Special Issue aims to emphasize key areas of therapeutic promise and highlight discoveries likely to be of significant future benefit in the treatment of disease.

Dr. Rajarshi Mukherjee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatitis
  • pathophysiology
  • inflammation
  • diagnostics
  • biomarkers
  • drug discovery

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Published Papers (2 papers)

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Research

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18 pages, 2050 KiB  
Article
Metabolites and Lipoproteins May Predict the Severity of Early Acute Pancreatitis in a South African Cohort
by Jeanet Mazibuko, Nnenna Elebo, Aurelia A. Williams, Jones Omoshoro-Jones, John W. Devar, Martin Smith, Stefano Cacciatore and Pascaline N. Fru
Biomedicines 2024, 12(11), 2431; https://doi.org/10.3390/biomedicines12112431 - 23 Oct 2024
Viewed by 1136
Abstract
Background: Acute pancreatitis (AP) can be life-threatening with unpredictable severity. Despite advances in management, its pathogenesis remains unclear. This study investigated metabolites and lipoprotein profiles in AP patients of African descent to understand the underlying pathophysiological conditions so as to inform prognosis and [...] Read more.
Background: Acute pancreatitis (AP) can be life-threatening with unpredictable severity. Despite advances in management, its pathogenesis remains unclear. This study investigated metabolites and lipoprotein profiles in AP patients of African descent to understand the underlying pathophysiological conditions so as to inform prognosis and management. Methods: Serum samples were collected from 9 healthy controls (HCs) and 30 AP patients (8 with mild AP, 14 with moderately severe AP, and 8 with severe AP) on days 1, 3, 5, and 7 post epigastric pain and subjected to nuclear magnetic resonance (NMR) spectroscopy. Wilcoxon and Kruskal–Wallis rank-sum tests compared numerical covariates. Lipoprotein characterization was performed using the Liposcale test, and Spearman’s rank test assessed data correlations. The p-values < 0.05 indicated significance. Results: Thirty-eight metabolic signals and information on lipoprotein subclasses were identified from the NMR spectra. The severity of AP correlated with increased levels of 3-hydroxybutyrate and acetoacetate and decreased levels of ascorbate. Distinct metabolic phenotypes were identified and characterized by unique inflammatory and lipoprotein profiles. High-density lipoprotein cholesterol (HDL-C) decreased across all the metabolic phenotypes of AP when compared with the HC, while elevated immediate density lipoprotein cholesterol (IDL-C) and very low-density lipoprotein cholesterol (VLDL-C) levels were observed. Time-dependent changes in metabolites were indicative of responsiveness to therapy. Conclusions: Our findings indicate that dysregulated metabolites and lipoproteins can be used to differentiate AP disease state and severity. Furthermore, integrating clinical parameters with data on metabolic and lipoprotein perturbations can contribute to a better understanding of the complex pathophysiology of AP. Full article
(This article belongs to the Special Issue Acute Pancreatitis: Biology, Diagnosis and Therapy)
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Review

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38 pages, 21275 KiB  
Review
Pancreatic Morphology, Immunology, and the Pathogenesis of Acute Pancreatitis
by Tudorel Mihoc, Silviu Constantin Latcu, Cosmin-Ciprian Secasan, Vlad Dema, Alin Adrian Cumpanas, Mircea Selaru, Catalin Alexandru Pirvu, Andrei Paul Valceanu, Flavia Zara, Cristina-Stefania Dumitru, Dorin Novacescu and Stelian Pantea
Biomedicines 2024, 12(11), 2627; https://doi.org/10.3390/biomedicines12112627 - 17 Nov 2024
Cited by 1 | Viewed by 3519
Abstract
Acute pancreatitis is a complex inflammatory disorder with significant morbidity and mortality. This review aims to integrate the current knowledge of pancreatic morphology and immunology with the pathogenesis of acute pancreatitis, providing a comprehensive understanding of this critical condition. We conducted an extensive [...] Read more.
Acute pancreatitis is a complex inflammatory disorder with significant morbidity and mortality. This review aims to integrate the current knowledge of pancreatic morphology and immunology with the pathogenesis of acute pancreatitis, providing a comprehensive understanding of this critical condition. We conducted an extensive literature review, synthesizing data from recent studies and authoritative sources on pancreatic anatomy, histology, immunology, and the pathophysiology of acute pancreatitis. We also incorporated epidemiological data, clinical features, diagnostic criteria, and prognostic factors. The pancreas exhibits a complex morphology with intricate interactions between its exocrine and endocrine components. Its unique immunological landscape plays a crucial role in maintaining homeostasis and orchestrating responses to pathological conditions. In acute pancreatitis, the disruption of intracellular calcium signaling leads to premature enzyme activation, triggering a cascade of events including mitochondrial dysfunction, ATP depletion, and the release of proinflammatory mediators. This process can escalate from localized inflammation to systemic complications. The interplay between pancreatic morphology, immune responses, and pathophysiological mechanisms contributes to the varied clinical presentations and outcomes observed in acute pancreatitis. Understanding the intricate relationships between pancreatic morphology, immunology, and the pathogenesis of acute pancreatitis is crucial for developing more effective diagnostic and therapeutic strategies. This integrated approach provides new insights into the complex nature of acute pancreatitis and may guide future research directions in pancreatic disorders. Full article
(This article belongs to the Special Issue Acute Pancreatitis: Biology, Diagnosis and Therapy)
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