The Roles of Age and Sex in Oxidative and Proteolytic Stress

Dear Colleagues,

Oxidative and proteolytic stress represent prominent features of a host of diseases including Parkinson’s disease, Alzheimer’s disease, cardiovascular disease, diabetes, cancer and sarcopenia. The capacity of an organism to manage and respond to such stresses is heavily driven by sex and age. This heterogeneity may explain the elevation of the prevalence of such diseases as a consequence of age and differences in susceptibility between the sexes.

At the cellular level, the onset and amount of cellular imbalance (such as proteolytic stress) are highly sexually dimorphic. Additionally, many of the beneficial outcomes evident from our current longevity interventions (pharmaceutical and dietary regimes) are favorable for only one sex. The age-dependent sex differences in longevity are also highly pervasive in chronic diseases, including cancer, metabolic syndrome, and neurological dysfunction. The present issue focuses on exploring these nuances from the cellular level to disease manifestation.

The scope of the issue will be focused on how proteolytic and oxidative stress are impacted by sex and increasing age and the roles of these factors in aging and disease. The purpose of the Special Issue is to combine timely reviews and current research focused on exploring how sex affects aging and chronic disease onset and progression from the perspective of oxidative and proteolytic damage. The exploration of this topic is important in understanding the role of oxidative stress in disease and how this is shaped by age and sex. Elucidating, at the cellular level, how aging manifests and progresses, specifically through oxidative and proteolytic stress, and the unique impact of sex will be highly valuable to a broad readership.

Dr. Laura Corrales-Diaz Pomatto
Dr. Andrew M. Pickering
Guest Editors

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• oxidative stress
• proteostasis
• mitochondrial dysfunction
• sexual dimorphism
• aging
• metabolic syndrome
• cancer
• neurological pathologies