Macrophages in Low Oxygen Environment
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 396
Special Issue Editor
Interests: tumor associated macrophages; macrophage polarization; innate Immunity; tumor microenvironment, hypoxia; inflammation; mechanobiology; phagocytosis; biomaterials
Special Issue Information
Dear Colleagues,
Macrophages are innate immune cells that are deeply involved in tissue homeostasis. These cells display a high phenotypic plasticity in response to their cellular microenvironment. Due to this plasticity, macrophages have been implicated in various pathological processes, such as cancers and chronic immune diseases. The importance of these cells is highlighted by the development of various targeting therapies focused on macrophages. Despite this progress, the molecular understanding of how these cells cope with various environmental signals is still poorly understood.
One particularly important characteristic of the cellular microenvironment is the oxygen availability. Due to its importance in the cellular environment, cells have developed molecular systems to sense oxygen, the fuel of intracellular bioenergetics. It has been demonstrated recently that a low-oxygen environment could have a greater impact on a macrophage’s biology than previously anticipated. A better understanding of how oxygen could participate in various immune functions driven by macrophages in normal and pathological situations is necessary.
This Special Issue welcomes the submission of original research and review manuscripts focusing on oxygen’s impact on macrophages’ functions in normal and pathological contexts. This Special Issue invites all functional and/or multi-omics approaches to characterize phenotypic modifications driven by oxygen.
Dr. Arnaud Millet
Guest Editor
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Keywords
- Macrophages
- hypoxia
- physioxia
- biomakers
- proteomics
- transcriptomics
- phagocytosis
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