Engineering Breast Cancer Subtype Specific Tumor Models
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 329
Special Issue Editor
Special Issue Information
Dear Colleagues,
Breast cancer is a heterogeneous disease that often develops resistance to therapy. The development of resistance to therapy is a significant obstacle to effective therapeutic regimens for both the primary tumor and in the metastatic setting. Evaluating the effects of oncology drugs in the laboratory setting is limited by the lack of translational models that accurately recapitulate cell–microenvironment interactions present in tumors. The tumor microenvironment provides biophysical, chemical, and biological stimuli that regulate cancer cell behavior, progression and drug resistance. The tumor microenvironment has been extensively studied in both cellular biology and tissue engineering; transdisciplinary works that integrate these two principals are crucial to the development of physiologically accurate tumor models of breast cancer. Topics of interest for this Special Issue include, but are not limited to, the following:
- Characterization of subtype-specific tumor microenvironments and matrix in tumor development and progression.
- Development of 3D tumors that incorporate stromal cells from patient-specific backgrounds in tumor models. Included within this is the production of tumor models that produce models specific to patient age, race, and body mass index.
- Matrix modulation of immune surveillance in cancer.
- Tissue-engineered technologies that allow for the evaluation of real time monitoring of breast cancer subtype-specific mediated tumor microenvironment remodeling.
- Tissue-engineered technologies that allow for the evaluation and monitoring of the effects of therapy on stromal cell populations.
- Engineered models of metastatic breast cancer that incorporate the evaluation of fluid shear stress and seeding at new tissue sites.
- Modulating physiochemical properties of engineered scaffolds to mimic metastatic sites such as the lung, brain, liver, or bone.
Prof. Elizabeth C. Martin
Guest Editor
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Keywords
- breast cancer
- tumor microenvironment
- matrix remodeling, engineering tumor models
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