Heterologous Microbial Production of Health-Promoting Natural Products
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biochemical Engineering".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 161
Special Issue Editor
Special Issue Information
Dear Colleagues,
Health‑promoting natural products play a vital role in medicine, nutrition, and biotechnology, yet traditional extraction from plants, animals, or native microbes is often constrained by low yields, long cultivation cycles, environmental limitations, and challenges in scalability. Advances in synthetic biology, metabolic engineering, and microbial chassis development now enable the efficient heterologous biosynthesis of diverse bioactive compounds, providing a sustainable and versatile alternative to conventional extraction approaches.
This Special Issue on “Heterologous Microbial Production of Health-Promoting Natural Products” highlights recent progress in engineering microbial systems for the production of natural products with therapeutic or nutraceutical value. We welcome original research articles and comprehensive reviews spanning pathway reconstruction, strain optimization, enzyme engineering, computational design, and fermentation development.
Topics of interest include, but are not limited to, the following:
- Engineering microbial hosts for heterologous biosynthesis of natural products;
- Reconstruction and optimization of plant, fungal, or microbial biosynthetic pathways;
- Synthetic biology tools for pathway assembly and dynamic regulation;
- Enzyme discovery, characterization, and engineering for natural product synthesis;
- Production of nutraceuticals, antioxidants, alkaloids, terpenoids, polyketides, flavonoids, and other bioactive metabolites;
- Metabolic flux analysis, systems biology, and computational modeling;
- Fermentation optimization and scale‑up strategies;
- CRISPR‑based genome engineering and high‑throughput screening for strain improvement;
- Integration of omics‑driven design, automation, or machine learning in natural product biomanufacturing.
Dr. Yuheng Lin
Guest Editor
Manuscript Submission Information
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Keywords
- microbial production
- heterologous host
- metabolic pathway engineering
- natural products
- health-promoting benefits
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