Biomaterials for Tissue Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 996

Special Issue Editors


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Guest Editor
CICECO- Aveiro Insitute of Materials, Department of Chemistry, Universidade de Aveiro, 3810-193 Aveiro, Portugal
Interests: biomaterials; tissue engineering; magnetic force-based tissue engineering; bone regeneration; controlled release; nanotechnology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
CICECO–Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: carbohydrates; peptides; self-assembly; biomaterials; drug/therapeutics delivery; tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials play a pivotal role in the field of tissue regeneration, offering innovative solutions for restoring, regenerating or substituting damaged tissues or organs. The selection of biomaterials, ranging from natural polymers to synthetic biodegradable counterparts, involves careful consideration of biocompatibility, mechanical and degradation kinetics. Advancements in (bio)fabrication techniques and the functionalization of biomaterials with bioactive molecules provide precise control over biophysical and biochemical cues necessary to induce regeneration by modulating the extracellular microenvironment or driving cellular reprogramming. This Special Issue entitled “Biomaterials for Tissue Regeneration” will focus on original research papers and comprehensive reviews covering the development of innovate biomaterials to address clinically relevant challenges. Original research papers on the dynamic interplay between biomaterials and cells highlighting their essential role in the regeneration of tissues or organs are highly encouraged. Articles discussing further advancing tissue-engineered products towards clinical practice will be also addressed.

Topics of interest for this Special Issue include, but are not limited to, the following:

  1. Instructive biomaterials;
  2. Smart biomaterials for tissue engineering;
  3. Nanostructured biomaterials for enhanced tissue engineering;
  4. 3D (bio)printing of biomaterials for drug/therapeutics delivery and tissue engineering;
  5. Immunomodulation in tissue regeneration using biomaterials.

Additional research areas focusing on the development of novel biomaterials for tissue regeneration will also be considered relevant.

Dr. Ana Sofia Silva
Dr. João Borges
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • instructive materials
  • tissue regeneration
  • biofabrication
  • cell instructive

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Published Papers (1 paper)

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Review

13 pages, 336 KiB  
Review
The Use of Gelatin Methacrylate (GelMA) in Cartilage Tissue Engineering: A Comprehensive Review
by Kush Savsani, Alexandra Hunter Aitchison, Nicholas B. Allen, Elsie A. Adams and Samuel B. Adams
Bioengineering 2025, 12(7), 700; https://doi.org/10.3390/bioengineering12070700 - 27 Jun 2025
Viewed by 609
Abstract
Cartilage injuries, due to their limited regenerative capacity, often result in chronic pain and functional impairment. These injuries are difficult to manage with conventional surgical repair techniques; therefore, alternative treatments are necessary. Gelatin methacrylate (GelMA) has emerged as a promising biomaterial for cartilage [...] Read more.
Cartilage injuries, due to their limited regenerative capacity, often result in chronic pain and functional impairment. These injuries are difficult to manage with conventional surgical repair techniques; therefore, alternative treatments are necessary. Gelatin methacrylate (GelMA) has emerged as a promising biomaterial for cartilage tissue engineering due to its biocompatibility, tunable mechanical properties, and ability to be used in advanced applications like 3D bioprinting. This review examines the synthesis, properties, and limitations of GelMA in cartilage repair, focusing on its applications in 3D bioprinting for the creation of patient-specific cartilage constructs. It also highlights preclinical studies exploring the potential of GelMA-based scaffolds in various animal models. Despite its advantages, challenges remain, such as the mechanical limitations of GelMA and its degradation rate in dynamic environments. Hybrid scaffolds, in situ bioprinting, and personalized bioinks offer solutions to these issues. Ultimately, long-term clinical trials are needed to assess the durability and efficacy of GelMA-based scaffolds in human applications. Future research is aimed at overcoming these challenges, improving the mechanical strength of GelMA scaffolds, and enhancing their clinical translation for cartilage repair. Full article
(This article belongs to the Special Issue Biomaterials for Tissue Regeneration)
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