CRISPR-Cas: Discovery, Function and Application
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (15 January 2021) | Viewed by 13284
Special Issue Editors
Interests: CRISPR; microbiology; biochemistry; gene regulation; epigenetics
Interests: CRISPR; microbiology; structural biology; biochemistry
Special Issue Information
CRISPR-Cas is a prokaryotic defense system that provides its host with an adaptive immunity against invading mobile genetic elements. These systems generally function by detecting foreign DNA or RNA based on complementarity to a small non-coding RNA guide to trigger a variety of nucleic acid degradation patterns for host protection. CRISPR-Cas systems are highly diverse in nature and recent efforts to optimize these systems through molecular engineering have converted CRISPR-Cas into a programmable “swiss-army” toolkit for biotechnological, therapeutic and diagnostic applications. With the increasing precision and safety of editing, CRISPR-Cas is not only being used for regular research but is also slowly approaching application in the clinic. In this special issue we will be interested but not limited to the following topics:
- Evolution and discovery of CRISPR-Cas systems
- Mechanisms of CRISPR-Cas function
- Natural regulation and control mechanisms of CRISPR activity
- Protein and RNA engineering approaches to achieve fine control of CRISPR-Cas activity
- Development of CRISPR-Cas based technologies for novel applications
- New and improved methods for the delivery of CRISPR tools
- Advances in alternative methods for genome editing
Dr. Haridha Shivram
Dr. Patrick Pausch
Dr. Xin D. Gao
Guest Editors
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