Retinal Circuit Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: closed (10 January 2025) | Viewed by 876

Special Issue Editors


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Guest Editor
Department of Information Engineering, Mie University, 1577 Kurima-machiya, Tsu 514-8507, Mie, Japan
Interests: visual neurophysiology; retinal circuit model; neuro-morphic hardware; visual prosthesis; edge machine learning inference; life-assistive intelligence

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Co-Guest Editor
Department of Human Intelligence Systems, Kyushu institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 808-0196, Japan
Interests: bio-inspired robot vision; retinal circuit model; neuro-morphic hardware; edge machine learning inference; hardware simulation

Special Issue Information

Dear Colleagues,

Neuroscience studies have revealed that biological neural circuits are equipped with various components that enable cost-effective and intelligent computation. As part of the central nervous system, the vertebrate neural retina receives photons and generates electrical spike signals that are sent to the brain. Investigating genetics, morphology, and physiology has led to identifying more than ten subtypes of retinal ganglion cells. These subtypes are thought to host parallel output channels that encode multiple different information into spatiotemporal patterns of spike signals. Retinal neuron types and their synaptic connections have been studied for decades as building blocks for circuits that route signals to those output channels. The light-induced response properties of retinal neurons have been measured by performing physiological experiments. Despite such advances in neuroscience, our theoretical and computational understanding of the retinal neural circuitry connecting the output channels is still premature for applying scientific knowledge to biomimetic robots or visual prostheses. On the other hand, machine learning methodologies have become increasingly popular in machine vision. Although machine visions are essentially different in their roles, properties, functions, and necessities from animals’ visions, technological progress in the field of machine learning may be useful for analyzing or recapturing the vertebrate retinal circuits, and, in turn, animals’ visions. For accelerating the quantitative understanding of vertebrate retinal circuits, this Special Issue on “Retinal Circuit Engineering” focuses on original research papers and comprehensive review papers dealing with vertebrate retinal circuits by means of physiological experiments, computational/hardware implementations, and prosthetic or robotic applications.

Dr. Yuki Hayashida
Dr. Shinsuke Yasukawa
Guest Editors

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Keywords

  • physiology
  • modeling
  • hardware
  • prosthesis
  • robot

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Published Papers (1 paper)

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10 pages, 307 KiB  
Brief Report
Association Between Optical Coherence Tomography Angiography (OCTA)-Based Retinal Vascular Densities and Empathy in Young Adults
by Bess Yin-Hung Lam, Carole Leung, Ka-Shun Lei, Kaiyip Choi and Henry H. L. Chan
Bioengineering 2025, 12(9), 902; https://doi.org/10.3390/bioengineering12090902 - 22 Aug 2025
Abstract
With the use of Optical Coherence Tomography Angiography (OCTA), the present study is the first study to examine if retinal vascular densities (vessel densities and perfusion densities) could be associated with empathetic levels in young and non-clinical adults. Methods: Fifty-one university students aged [...] Read more.
With the use of Optical Coherence Tomography Angiography (OCTA), the present study is the first study to examine if retinal vascular densities (vessel densities and perfusion densities) could be associated with empathetic levels in young and non-clinical adults. Methods: Fifty-one university students aged from 18 to 25 years (26 males and 24 females) were recruited from a university in Hong Kong. OCTA was conducted to assess their retinal vessel density (VD) and perfusion density (PD) in different scan patterns over the macula (1 mm center subfield, 3 × 3 mm scan, 6 × 6 mm scan). Empathy (cognitive, affective, and somatic) was measured by using the Cognitive, Affective, and Somatic Empathy Scales (CASES). Results: After controlling for age, the multiple linear regression results showed that both the VD and PD in the 1 mm center subfield were significantly and negatively associated with the empathy total score, the affective empathy subscore, and the somatic empathy subscore, respectively (ps < 0.05). Conclusion: The present findings indicate that a lower level of empathy is associated with increased retinal vascular densities in the 1 mm center subfield, specifically involving variations in vascular density (VD) and perfusion density (PD). This suggests the dilation of retinal venules might lead to lower empathy. These results establish a foundation for future studies investigating the underlying mechanism of retinal imaging and empathy in healthy individuals. Full article
(This article belongs to the Special Issue Retinal Circuit Engineering)
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