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Advances in Dental and Oral Surgery

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 1950

Special Issue Editors


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Guest Editor
Department of Biomedical, Dental Sciences and Morphological and Functional Images, University Hospital “G. Martino”, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy
Interests: botulinum toxin; BonTA; maxillofacial surgery; orthognatic surgery; TMJ; salivary glands; facial nerve; sialolithiasis; sialendoscopy; scialendoscopy; oral cancer; OSCC; head and neck cancer; head an neck surgery; MRONJ; facial trauma; head and neck recon

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Guest Editor
Department of Medicine and Surgery, Kore University of Enna, Cittadella Universitaria, 94100 Enna, Italy
Interests: oral surgery

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Guest Editor
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio, 6, 80138 Naples, Italy
Interests: oral

Special Issue Information

Dear Colleagues,

In recent years, the field of dental and oral surgery has seen remarkable progress driven by technological innovations and new research. These advancements have not only enhanced the precision and efficacy of surgical procedures but have also significantly improved patient outcomes and recovery times. From the development of minimally invasive techniques to the application of regenerative medicine, the landscape of oral healthcare is being transformed in unprecedented ways.

The editorial board invites submissions for this Special Issue dedicated to the latest advancements in dental and oral surgery. This section is intended to highlight novel research, innovative surgical techniques and workflows, and emerging technologies that are transforming oral healthcare.

The focus is on topics including the following:

  • Minimally invasive surgical procedures.
  • Regenerative medicine in oral surgery.
  • Salivary gland pathology and surgery.
  • Biocompatible materials and prosthetics.
  • Digital imaging and diagnostics.
  • Digital Interventions: application of virtual planning, 3D printing, and CAD/CAM in surgery to promote personalized medicine.
  • The impact of digital dentistry and artificial intelligence on surgical outcomes for advanced data analysis, predictive diagnostics, and decision-making tools in oral health.
  • Innovations in dental implantology.

We are particularly interested in work that explores novel methodologies and technologies that have the potential to revolutionize dental and oral surgery. We look forward to receiving your submissions and collectively shaping the future of oral healthcare.

Dr. Giorgio Lo Giudice
Dr. Enrico Nastro Siniscalchi
Dr. Ciro Emiliano Boschetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral surgery
  • minimally invasive surgery
  • salivary glands surgery
  • regenerative medicine
  • imaging techniques
  • dental implantology
  • biocompatible materials
  • digital dentistry

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Published Papers (2 papers)

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Research

11 pages, 1138 KB  
Article
Internal Carotid Artery Anatomical Variants and Their Association with Increased Thromboembolic Risk in Vascular Eagle Syndrome
by Giorgio Lo Giudice, Samuele Cicchiello, Alessandro Calvo, Francesco Saverio De Ponte and Enrico Nastro Siniscalchi
Appl. Sci. 2025, 15(24), 13085; https://doi.org/10.3390/app152413085 - 12 Dec 2025
Abstract
Eagle Syndrome (ES), characterized by an elongated styloid process, has a vascular variant that risks cerebrovascular complications due to Internal Carotid Artery (ICA) compression. The role of pre-existing ICA anatomical variations (tortuosity, kinking, looping) in modulating this risk is unclear. This study aimed [...] Read more.
Eagle Syndrome (ES), characterized by an elongated styloid process, has a vascular variant that risks cerebrovascular complications due to Internal Carotid Artery (ICA) compression. The role of pre-existing ICA anatomical variations (tortuosity, kinking, looping) in modulating this risk is unclear. This study aimed to explore the relationship between vascular ES, ICA variants, and thromboembolic risk. We conducted an observational retrospective study on 37 confirmed vascular ES patients in Messina, Italy (2019–2024), collecting data on styloid length, ICA variant type, and the CHA2DS2-VASc score. ICA anomalies were highly prevalent (96% of arteries). Crucially, while no correlation was found between styloid length and the CHA2DS2-VASc score, a statistically significant association was detected between the ICA anatomical variant type and the CHA2DS2-VASc score (Fisher’s exact test p = 0.024). This suggests that ICA morphology, rather than styloid length alone, is associated with an elevated thromboembolic risk profile in vascular ES patients, emphasizing the need for detailed CT angiography evaluation to guide personalized management. Full article
(This article belongs to the Special Issue Advances in Dental and Oral Surgery)
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14 pages, 2746 KB  
Article
Assessment of the Efficacy of Dentin Graft and Xenograft in Bone Regeneration and the Enhancing Effect of Mesenchymal Stem Cells
by Sinan Yasin Ertem and Huseyin Tutku Bekar
Appl. Sci. 2025, 15(21), 11511; https://doi.org/10.3390/app152111511 - 28 Oct 2025
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Abstract
Background/Objectives: The use of dentin grafts in bone regeneration has gained increasing attention as an alternative to conventional grafting materials. Mesenchymal stem cells (MSCs), known for their osteogenic potential, have been combined with various biomaterials to enhance regenerative outcomes. This study aimed to [...] Read more.
Background/Objectives: The use of dentin grafts in bone regeneration has gained increasing attention as an alternative to conventional grafting materials. Mesenchymal stem cells (MSCs), known for their osteogenic potential, have been combined with various biomaterials to enhance regenerative outcomes. This study aimed to evaluate the regenerative potential of dentin grafts and bovine-derived xenografts, with or without MSCs, in experimentally created bone defects in a rat model. Methods: A total of 25 male rats were randomly assigned to five groups: control, dentin graft, dentin graft and MSC, xenograft, and xenograft and MSC. Standardized 2-mm cortical defects were created bilaterally in the femoral shafts. Histological and immunohistochemical analyses were performed after a 90-day healing period. Statistical evaluation was carried out using the Kruskal–Wallis H test and Bonferroni-adjusted pairwise comparisons. Results: Complete healing was achieved in all groups without evidence of complications or inflammatory reactions. Immunohistochemical staining demonstrated no positive vascular endothelial growth factor (VEGF), collagen type I (COL1), or osteopontin (OPN) reactions in defect areas, consistent with complete maturation, although collagen type 3 (COL3) positivity was observed in residual xenograft material. Quantitative analysis showed that the dentin graft and MSC group achieved the highest degree of new bone formation (M = 92.88%, SD = 6.09), significantly greater than the control (p = 0.002) and xenograft groups (p = 0.013). Conclusions: Both dentin grafts and xenografts demonstrated enhanced bone defect healing when combined with MSCs. Nevertheless, dentin grafts in conjunction with MSCs yielded the most favorable regenerative outcomes, suggesting their clinical superiority over conventional xenografts. Full article
(This article belongs to the Special Issue Advances in Dental and Oral Surgery)
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