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Applied Sciences
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Recent Advances in Bioadhesives for Tissue Repair
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Recent Advances in Bioadhesives for Tissue Repair

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 9006

Special Issue Editors

Prof. Dr. L. John R. Foster

E-Mail Website
Guest Editor
Chemistry Department, The University of Alabama in Huntsville, 301 Sparkman Drive, Material Science Building, MSB C203B, Huntsville, AL 35899, USA
Interests: biomaterials; medical devices; wound healing; biopolymers; biocompatible; biodegradable; chitosan; polyhydroxyalkanoates; PHAs
Dr. Helder Marcal

E-Mail Website
Guest Editor
Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
Interests: tissue engineering; biomedical engineering; tissue regeneration; proteomics; bio-medical applications; biomaterials; regenerative medicine

Special Issue Information

Dear Colleagues,

Medical professionals remain reliant upon sutures for wound closure. Despite advances in suture design, this ancient technology has significant disadvantages for effective tissue repair. In response, the development and subsequent commercial application of surgical adhesives continue to increase in popularity. Surgical adhesives are now used as standard in many medical procedures. Numerous studies show that not only do surgical adhesives effect wound closure but help to seal wounds, reduce infection and scar tissue, and enhance functional tissue regeneration.

This Special Issue is devoted to surgical adhesives developed from biological components. While all submissions relating to bioadhesives will be considered, we particularly welcome those that report their application in vivo.

Prof. Dr. L. John R. Foster
Dr. Helder Marcal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Surgical adhesive
  • Wound repair
  • Tissue regeneration
  • Medical devices
  • Biomaterials
  • Biopolymers

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Published Papers (2 papers)

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Research

10 pages, 1201 KiB  
Article
Application of a Novel Film Sealant Technology for Penetrating Corneal Wounds: An Ex-Vivo Study
by Jackie Tan, Leslie John Ray Foster and Stephanie Louise Watson
Appl. Sci. 2020, 10(9), 3193; https://doi.org/10.3390/app10093193 - 3 May 2020
Cited by 6 | Viewed by 3476
Abstract
Aim: To compare the burst pressures of corneal wounds closed with a laser-activated, chitosan-based thin film adhesive against self-seal, sutures and cyanoacrylate. Methods: 2, 4 or 6 mm penetrating corneal wounds were created on 100 freshly enucleated bovine eyes. The wounds were closed [...] Read more.
Aim: To compare the burst pressures of corneal wounds closed with a laser-activated, chitosan-based thin film adhesive against self-seal, sutures and cyanoacrylate. Methods: 2, 4 or 6 mm penetrating corneal wounds were created on 100 freshly enucleated bovine eyes. The wounds were closed using a laser-activated chitosan adhesive (n = 30), self-sealed (control) (n = 30), sutures (n = 20) or cyanoacrylate glue (Histoacryl®) (n = 20). The corneoscleral rim was dissected and mounted onto a custom burst pressure testing chamber. Water was pumped into the chamber at 9ml/hr. The fluid pressure prior to wound leakage was recorded as the ‘burst pressure’. Results: The burst pressure for the 2, 4 and 6 mm wounds were 239.2 mmHg (SD = ±102.4), 181.7 mmHg (SD = ±72.8) and 77.4 mmHg (SD = ±37.4) (p < 0.00001), respectively, for chitosan adhesive. Burst pressure was 36.4 mmHg (SD = ±14.7), 4.8 mmHg (SD = ±4.9) and 2.7 mmHg (SD = ±1.3) (p < 0.00001), respectively, for the self-sealed group. For 4 and 6mm wounds, burst pressures with sutures were 33.0 mmHg (SD = ±19) and 23.5 mmHg (SD = ±17.4) (p = 0.0087), respectively. For cyanoacrylate, burst pressures for 2 and 4 mm wounds were 698 mmHg (SD = ±240.3) and 494.3 mmHg (SD = ±324.6) (p = 0.020087), respectively. Conclusion: This laser-activated chitosan-based adhesive sealed bovine corneal wounds up to 6 mm in length. Burst pressure was higher for the adhesive than sutured or self-sealed wounds, but lower than for cyanoacrylate. Full article
(This article belongs to the Special Issue Recent Advances in Bioadhesives for Tissue Repair)
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14 pages, 2348 KiB  
Article
α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis
by Nasrul Wathoni, Nia Yuniarsih, Arief Cahyanto and Muhctaridi Muhctaridi
Appl. Sci. 2019, 9(23), 5235; https://doi.org/10.3390/app9235235 - 2 Dec 2019
Cited by 21 | Viewed by 5003
Abstract
Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound [...] Read more.
Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound healing agent. In addition, hydrogel film as dressings designed to separate mucosal lesions from the oral environment, and improve the effectiveness of RAS therapy. The purpose of this study was to develop α-M hydrogel film based chitosan–alginate (ChAlg/α-M HF) for RAS. The in silico study by Discovery studio visualizer and AutoDock confirmed that hydrogen bonding between Ch, Alg, and α-M occurred. The results of physicochemical characterizations by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) indicated that the ChAlg/α-M HF had a lower crystalline form compared to pure α-M. In addition, ChAlg/α-M HF significantly improved the swelling ratio and tensile strength compared to that of ChAlg HF. Moreover, the existence of Alg increased the degradability of Ch, and closely related to the release of α-M from ChAlg HF. The in vitro release study confirmed that the release of α-M from ChAlg/α-M HF was the Fickian diffusion model. Finally, the mucoadhesive study revealed that ChAlg/α-M HF had a good mucoadhesive property. These results suggest that hydrogel film-based chitosan–alginate have the potential as carriers of α-M for RAS therapy. Full article
(This article belongs to the Special Issue Recent Advances in Bioadhesives for Tissue Repair)
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