applsci-logo

Journal Browser

Journal Browser

Bioactive Lipids: Chemical, Biological Properties and Pharmaceutical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 8109

Special Issue Editors


E-Mail Website
Guest Editor
Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy
Interests: marine natural products; drug disovery; medicinal chemistry; structure elucidation; qualitative and quantitative analysis of organic compounds; lipids
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Biomolecular Chemistry, Cnr Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy
Interests: immunology; natural product drug discovery; cell biology; inflammation; microalgae
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lipids are a large and diverse group of naturally occurring organic compounds with a great structural variety among the different chemical classes. They are biologically active and ubiquitous metabolites that have different functions from structural cell components, including energy storage and signaling. Over 100,000 bioactive lipids have been identified as signaling molecules involved in the regulation of molecular mechanisms in both physiologic and pathologic systems, such as arthritis, cancer, heart disease, obesity, and neurodegenerative disorders. Therefore, a characterization of new lipidic molecules such as a deeper understanding of their cellular functions, from cell signaling to metabolic and gene regulation, could unveil the role of these lipids as diagnostic or prognostic biomarkers of disease.

This Special Issue will cover all fields of research in bioactive lipids, including chemical and biological properties, the isolation and structure characterization of new lipids, mechanisms of action and medicinal applications, synthetic approaches, and new methods for the purification and quantification of active lipids.

Dr. Genoveffa Nuzzo
Dr. Carmela Gallo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive metabolites
  • lipids
  • cellular signaling
  • lipid biology
  • lipid chemistry

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

26 pages, 3315 KiB  
Review
A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance
by Ishan Ghai
Appl. Sci. 2023, 13(7), 4238; https://doi.org/10.3390/app13074238 - 27 Mar 2023
Cited by 22 | Viewed by 7419
Abstract
Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment. This outer membrane contains many protein channels, also known as porins [...] Read more.
Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment. This outer membrane contains many protein channels, also known as porins or nanopores, which mainly allow the influx of hydrophilic compounds, including antibiotics. One probable way bacteria may possibly develop antibiotic resistance is by reworking to reduce the inflow through these outer membrane porins or nanopores. The challenge now is to recognize and potentially comprehend the molecular basis of permeability via the bacterial outer membrane. To address this challenge, this assessment builds upon the author’s previous work to develop a comprehensive understanding of membrane porins and their crucial role in the influx of antibiotics and solutes. Furthermore, the work aspires to investigate the bacterial response to antibiotic membrane permeability and nurture discussion toward further exploration of the physicochemical parameters governing the translocation/transport of antibiotics through bacterial membrane porins. By augmenting our understanding of these mechanisms, we may devise novel approaches to mitigate antibiotic resistance in Gram-negative bacteria. Full article
Show Figures

Figure 1

Back to TopTop