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Advancements in Antimicrobial Nanomaterials: From Characterization to Practical Applications

A special issue of Applied Sciences (ISSN 2076-3417).

Deadline for manuscript submissions: 20 January 2026 | Viewed by 522

Special Issue Editor


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Guest Editor
Laboratory of Oral Microbiology Research, Microbiology and Parasitology Department, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil
Interests: biofilms; antimicrobial resistance; natural products; nanotechnology; bacteriology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global rise in antimicrobial resistance has intensified the search for innovative solutions that can control and prevent infections across clinical, industrial, and environmental settings. In this context, nanotechnology has emerged as a powerful tool, offering novel antimicrobial materials with enhanced efficacy, targeted delivery, and unique physicochemical properties.

This Special Issue of the Journal of Applied Sciences is dedicated to showcasing recent advancements in the design, synthesis, characterization, and application of antimicrobial nanomaterials. We welcome original research articles, reviews, and short communications that explore a wide range of nanomaterials, including but not limited to metallic and metal oxide nanoparticles, polymeric nanocomposites, carbon-based nanostructures, hybrid systems, and functionalized nanocarriers.

Topics of interest include:

  • Novel strategies for Antimicrobial nanomaterial synthesis and functionalization;
  • Mechanisms of antimicrobial action at the nanoscale;
  • Toxicological and biocompatibility assessments of antimicrobial nanoparticles;
  • Integration into coatings, textiles, packaging, and biomedical devices: focus on antimicrobial nanoparticles
  • Applications of nanoparticles in human and veterinary medicine, food safety, water treatment, surface disinfection, and others.

Prof. Dr. Roberto Christ Vianna Santos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • antimicrobial
  • resistance
  • bacteria
  • fungi
  • virus

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Published Papers (1 paper)

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Research

14 pages, 1592 KB  
Article
Cymbopogon flexuosus and Eugenol Nanoemulsion: Formulation, Stability, Antimicrobial Efficacy, and In Vitro Safety Assessment
by Franciane Batista Nunes, Ruth Barin, Larissa da Silva Silveira, Michele Rorato Sagrillo, Leonardo Vidal Zancanaro, Vitória Fernanda Belmonte Novais, Aline Ferreira Ourique, André Gündel, Cristiano Rodrigo Bohn Rhoden and Roberto Christ Vianna Santos
Appl. Sci. 2025, 15(18), 10214; https://doi.org/10.3390/app151810214 - 19 Sep 2025
Viewed by 348
Abstract
Pseudomonas aeruginosa and Staphylococcus aureus are highly resistant microorganisms that contribute to prolonged hospital stays and increased mortality. Developing new antimicrobial agents is essential to address this global health challenge. Nanoemulsions (NE) containing essential oils (EOs) and phenolic compounds with antimicrobial activity represent [...] Read more.
Pseudomonas aeruginosa and Staphylococcus aureus are highly resistant microorganisms that contribute to prolonged hospital stays and increased mortality. Developing new antimicrobial agents is essential to address this global health challenge. Nanoemulsions (NE) containing essential oils (EOs) and phenolic compounds with antimicrobial activity represent a promising alternative. This study reports, for the first time, the formulation of a NE containing Cymbopogon flexuosus and eugenol (NECE) and its antimicrobial activity against P. aeruginosa and S. aureus. NECE exhibited suitable physicochemical properties (mean size < 200 nm, PDI < 0.3, and negative zeta potential) and remained stable for 90 days at 4 °C while maintaining antimicrobial activity. It showed bactericidal effects at 2.5 mg/mL against P. aeruginosa and 0.625 mg/mL against S. aureus. Moreover, NECE improved the biocompatibility of the free oil (FO) in Peripheral Blood Mononuclear Cells (PBMCs). Altogether, these findings demonstrate, for the first time, that NECE is a stable nanoemulsion with enhanced antimicrobial activity and biocompatibility, supporting its potential as a safe and effective topical strategy against wound-associated pathogens. Full article
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