Brain-on-Chip Platforms: Advancing Neuroscience and Drug Discovery
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 134
Special Issue Editor
Interests: microphysiological system; organoid; tissue engineering; mechanotransduction; microfluidics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurological and psychiatric disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and schizophrenia, remain difficult to study and treat due to the complexity of the human brain. Traditional animal models and 2D cultures often fail to replicate human-specific brain architecture and function, limiting the success of drug development. Brain-on-chip technology, combined with induced pluripotent stem cells (iPSCs) and brain organoid models, offers a transformative approach to studying brain function and disease. These platforms integrate microfluidics, bioengineering, and bioelectronics to recreate key aspects of brain physiology, including neuronal networks, blood–brain barrier (BBB) function, and neuroinflammation, providing more accurate disease models and drug testing environments.
Key advancements include the following:
- iPSC-Derived Neurons and Organoids: Enabling patient-specific disease modeling and precision medicine;
- Blood-Brain Barrier-on-Chip: Improving drug permeability studies and neurovascular research;
- 3D Tissue Engineering and Microfluidics: Enhancing physiological relevance and dynamic brain interactions;
- High-Throughput Drug Screening: Identifying potential neurotherapeutics more efficiently;
- Neuroengineering: Advancing neural interfaces, brain–machine interactions, and machine learning.
Despite its promise, challenges remain in scalability, reproducibility, and long-term culture stability. This Special Issue will explore the latest innovations in brain-on-chip, iPSC-derived models, and organoid technology, bringing together experts in neuroscience, bioengineering, and drug discovery to drive progress in next-generation brain research.
We look forward to receiving your contributions.
Prof. Dr. Yeoheung Yun
Guest Editor
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Keywords
- iPSC
- organoid
- neurological and psychiatric disorders
- brain–on-chip
- neuroscience
- drug discovery
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