Nanobiopolymers in Medicine and Healthcare

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 3915

Special Issue Editors


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Guest Editor
School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK
Interests: cancer biology; drug delivery; gene therapy; biopolymers

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Guest Editor
Faculty of Environment, University of Leeds, Woodhouse, Leeds LS2 9JT, UK
Interests: biopolymers; water treatment; adsorption chemistry; nanotechnology

Special Issue Information

Dear Colleagues,

The special issue on nanobiopolymers covers major areas of medicine and healthcare namely, nano-theranostics, drug delivery, nanophotosensitizers, nanocomposites for healthy food packaging, nanoneutraceuticals and sanitization. The section on medicine would emphasize innovative synthesis and application of specialized nanobiopolymers/composites which could serve as efficient and ‘safe’ agents for nano-theranostics (supraparamagnetic nanopolymers, SPIONS, gadolinium based, chitosan and PLGA based, conjugated fluorescent nanopolymers etc), drug/oil encapsulation (antimicrobial agents), drug delivery, photosensitizers for photodynamic therapy (non titania based), gene therapy (using advanced RNA techniques) and advanced orthopaedics (nanofibers, multidimensional nanostructures, PLGA, collagen and Hyaluronic acid based nano fibrous scaffolds, Bioglass based nanocomposites).

The section on healthcare includes nanoneutraceuticals, healthy food packaging and sanitization with a special emphasis on research/review which would be industry oriented. Nanoneutraceuticals is an emerging area under pharmaceuticals. These would include natural polymers or polymer functionalized natural compounds for applications in various fields like cancer therapeutics, allergies, poisoning, mental well being and child probiotics. Innovative articles on food packaging would thrust on nanocomposites with emphasis on water solubility, antibacterial and mechanical properties. Water and sanitization would comprise of research being conducted on specialized nanobiopolymers being more pH stable, reusable, possess least disposal issues and act against a wide spectra of pollutants responsible for water borne diseases. 

The issue supports full length research articles, reviews, short communications and editorials.

Dr. Arindam Pramanik
Dr. Devlina Das Pramanik
Guest Editors

Manuscript Submission Information

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Published Papers (1 paper)

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Research

15 pages, 3894 KiB  
Article
Characterization of a Human In Vitro Intestinal Model for the Hazard Assessment of Nanomaterials Used in Cancer Immunotherapy
by Matthew Gibb, Sahar H. Pradhan, Marina R. Mulenos, Henry Lujan, James Liu, James D. Ede, Jo Anne Shatkin and Christie M. Sayes
Appl. Sci. 2021, 11(5), 2113; https://doi.org/10.3390/app11052113 - 27 Feb 2021
Cited by 5 | Viewed by 3522
Abstract
There is momentum in biomedical research to improve the structure and function of in vitro intestinal models that better represent human biology. To build a more comprehensive model, three human cell-types were co-cultured and characterized: i.e., HT29-MTX (intestinal mucous-producing goblet cells), Caco-2 (colon [...] Read more.
There is momentum in biomedical research to improve the structure and function of in vitro intestinal models that better represent human biology. To build a more comprehensive model, three human cell-types were co-cultured and characterized: i.e., HT29-MTX (intestinal mucous-producing goblet cells), Caco-2 (colon epithelial cells), and Raji B (lymphocytes). Raji B cells transformed a subpopulation of Caco-2 epithelial cells into phagocytic and transcytotic immune-supporting microfold cells (M-cells). A suite of bioassays was implemented to investigate steady-state barrier integrity and cellular communication. The model demonstrated a potentiating effect in metabolism and pro-inflammatory markers. Barrier integrity and cell seeding density seem to play a role in the reliability of endpoint readouts. Microscopic analysis elucidated the importance of multi-cell biomimicry. The data show that monocultures do not have the same characteristics inherent to triple cell culture models. Multiple cell types in an in vitro model produce a better representation of an intact organ and aid in the ability to assess immunomodulatory effects of nanomaterials designed for cancer theranostics after ingestion. As many national and international agencies have stressed, there is a critical need to improve alternative-to-animal strategies for pharmaceuticals in an effort to reduce animal testing. Full article
(This article belongs to the Special Issue Nanobiopolymers in Medicine and Healthcare)
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