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Advanced Biotechnologies and Clinical Developments in Dentistry and Oral and Maxillofacial Surgery: 2nd Edition

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 30 January 2026 | Viewed by 341

Special Issue Editor


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Guest Editor
University Outpatient Clinic for Conservative Dentistry and Periodontology, Martin-Luther-University Halle-Wittenberg, 06112 Halle, Germany
Interests: restorative dentistry; dental; operative dentistry; aesthetic dentistry; endodontics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, various materials have been used in dental practice. In dentistry and oral and maxillofacial surgery, they play a decisive role in the success of the treatment. In practice, certain trends have become established and well accepted in their application. In order to improve the quality of treatments and to avoid serious side effects, knowledge is needed about the application of new technologies, the short- and long-term interactions of them with oral tissues, and their biological effects. For this reason, in recent years, these materials have been scientifically investigated in numerous in vitro and in vivo studies and have had an impact on clinical treatments.

This Special Issue reviews some recent significant innovations applied in major branches of dentistry such as conservative dentistry, prosthodontics, oral surgery, and oral and maxillofacial surgery.
An excerpt of possible topics is listed below and can be added to:

  • Recent developments in dental and surgical technologies;
  • Actual developments in digital dentistry;
  •  Advanced biotechnologies in the treatment of cervical dentin hypersensitivity;
  • Advanced biotechnologies in endodontics;
  • Advanced biotechnologies and clinical results using adhesive materials in dentistry;
  • The influence of tumor therapeutic radiotherapy in the head/neck region on dental materials and oral tissues.

It is, therefore, my pleasure to invite you to submit research on these topics in the form of original papers, reviews, or clinically useful diagnostic approaches.

Prof. Dr. Christian Ralf Gernhardt
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adhesive omaterials
  • clinical outcome
  • endodontics oral
  • surgery prosthetics
  • implantology bone
  • regeneration pain
  • dentin hypersensitivity

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Published Papers (1 paper)

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Research

11 pages, 436 KB  
Article
Mutagenicity Evaluation of Orthodontic Resins Using the Ames Test
by Roberto Biagi, Gianna Dipalma, Federica Macrì, Niccolò Cenzato, Cinzia Maspero and Lucia Giannini
Appl. Sci. 2025, 15(19), 10351; https://doi.org/10.3390/app151910351 - 24 Sep 2025
Viewed by 120
Abstract
The biocompatibility of orthodontic materials is crucial for patient safety, especially concerning their possible mutagenic effects. This study aimed to assess the mutagenic potential of three commercially available orthodontic resins using the Ames test. We tested Resin A, Resin B, and Resin C, [...] Read more.
The biocompatibility of orthodontic materials is crucial for patient safety, especially concerning their possible mutagenic effects. This study aimed to assess the mutagenic potential of three commercially available orthodontic resins using the Ames test. We tested Resin A, Resin B, and Resin C, which consist of a base and an accelerator component. We used Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537, along with TA1538, both with and without metabolic activation (S9 mix), following standardized protocols. After 48 h, we counted the number of revertant colonies and analyzed the data using two-way ANOVA. The Ames test revealed that Resins A and B induced significant mutagenic activity in strains TA100 and TA1535, with increases in revertant colonies up to about +145% compared with controls, while no effects were observed in TA98, TA1537, or TA1538. Resin C (both the complete mix and the base component) also showed mutagenicity in TA100 and TA1535, whereas the accelerator alone was consistently non-mutagenic. Positive controls confirmed the test system’s sensitivity. In conclusion, some orthodontic resins and their components showed mutagenic activity under the tested conditions. This highlights the need for mutagenicity testing as part of the biological safety assessment of dental materials. Full article
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