Gene–Diet Interactions in Chronic Disease: Advances in Nutrigenomics and Nutritional Interventions
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 2
Special Issue Editors
2. PhD School of Applied Medical-Surgical Sciences, University of Rome “Tor Vergata”, 00133 Rome, Italy
Interests: nutrition; diet; Mediterranean diet
Interests: Mediterranean diet; eating behaviour; body composition; DXA; BIA; energy expenditure; clinical nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic non-communicable diseases, such as cardiovascular disease, obesity, type 2 diabetes, and certain cancers, arise from multifaceted interactions between genetic predispositions and environmental factors, with diet playing a central role. The growing field of nutrigenomics seeks to unravel how nutrients modulate gene expression, offering the potential for highly personalized dietary strategies to prevent or manage chronic disease. Increasing evidence suggests that genetic variants, epigenetic modifications, and microbiome composition influence individual responses to nutrition and that sex differences may significantly impact gene–diet interactions and related health outcomes.
This Special Issue aims to compile high-quality contributions that explore the complex interplay between genetic makeup and dietary exposures in the context of chronic disease. Topics of interest include, but are not limited to, the following:
- Gene–diet interactions and chronic disease risk;
- Sex-specific responses to nutritional interventions;
- Epigenetic modifications induced by dietary factors;
- Microbiome-mediated gene–nutrient interactions;
- Omics technologies in personalized nutrition;
- Nutrigenetics and precision medicine approaches;
- Clinical trials testing genotype-based nutritional interventions;
- Biomarkers for personalized dietary strategies.
We welcome original research articles, clinical studies, reviews, and comparative studies and particularly encourage the submission of contributions that bridge the gap between molecular insights and translational applications.
Dr. Giulia Frank
Dr. Paola Gualtieri
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nutrigenomics
- gene–diet interactions
- chronic disease
- personalized nutrition
- epigenetics
- sex differences
- precision medicine
- nutritional interventions
- omics technologies
- microbiome and diet
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