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Bio-Materials in Regenerative Medicine
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Bio-Materials in Regenerative Medicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (30 October 2022) | Viewed by 5990

Special Issue Editor

Prof. Dr. Jeong Ok Lim

E-Mail Website
Guest Editor
Kyungpook National University Hospital, Daegu 41944, Korea
Interests: tissue engineering; oxygen; scaffolds; biomaterials; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Regenerative medicine is an emerging multidisciplinary field involved in biology, engineering, materials science, genetics, and medicine, aiming to replace tissues and restore the function of damaged tissues and organs. Biomaterials have a pivotal role in regenerative medicine by providing a microenvironment for structural support, cell adhesion, connection, and growth required for tissue formation. Various biomaterials are available, including natural and synthetic polymers, hydrogels, bioactive ceramics, and composites; others are under rigorous development for the engineering of living tissues or functional organs. Through the use of biomaterials, novel technologies such as 3D printing and organoid fabrication are being developed to introduce the next era of regenerative medicine. The success of regenerative medicine is, therefore, highly dependent on the use of suitable biomaterials that can support and guide cells during healing and remodeling processes.

In this Special Issue on “Biomaterials in Regenerative Medicine”, we plan to present recent advances in basic and translational research regarding biomaterials in regenerative medicine.

The scope of this Special Issue includes the following subjects:

  • the design, synthesis, and formulation of novel biomaterials for tissue engineering and regenerative medicine applications;
  • cell carrier for cell-based therapies;
  • wound healing;
  • organoid;
  • ECM;
  • drug delivery system for regenerative medicine;
  • clinical application of biomaterials;
  • 3D printing and bioink.

Prof. Dr. Jeong Ok Lim
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (2 papers)

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Research

13 pages, 6171 KiB  
Article
Effect of a Silk Sericin and Methylsulfonylmethane (MSM) Blends on Inflammatory Response and Wound Healing
by Hyun-Lyung Jeong, Eun-Bin Kang, Seung-Geun Yun, Dan-bi Park, Jeong-Ok Lim and Jang-Soo Suh
Appl. Sci. 2023, 13(1), 288; https://doi.org/10.3390/app13010288 - 26 Dec 2022
Cited by 9 | Viewed by 3364
Abstract
The natural product silk sericin has excellent biological properties, such as biocompatibility, biodegradability, and antioxidant activity, and it also facilitates cell proliferation, collagen type 1 production, and wound healing. Methylsulfonylmethane (MSM) is a natural organic sulfur compound known to relieve pain and inflammation. [...] Read more.
The natural product silk sericin has excellent biological properties, such as biocompatibility, biodegradability, and antioxidant activity, and it also facilitates cell proliferation, collagen type 1 production, and wound healing. Methylsulfonylmethane (MSM) is a natural organic sulfur compound known to relieve pain and inflammation. In this study, we formulated sericin and MSM blends in various ratios, and investigated their effects on the inflammatory response and subsequent healing of a wound in vitro using macrophages and fibroblasts. The experimental findings, derived from cell viability analyses and nuclear factor kappa B (NFκB)/cyclooxygenase-2 (COX-2)/inducible nitric oxide synthase (iNOS) pathway assays, demonstrated that the anti-inflammatory activity of MSM was more effective when it was blended with sericin. In contrast, MSM alone did not enhance wound healing but rather delayed it at higher concentrations. We confirmed that the blend of sericin and MSM exhibited a synergistic effect on suppressing inflammatory responses and promoting subsequent wound healing when the two materials were optimally blended. Full article
(This article belongs to the Special Issue Bio-Materials in Regenerative Medicine)
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15 pages, 6049 KiB  
Article
Application of Graphene Oxide as a Biomaterial for the Development of Large-Area Cell Culture Vessels
by Jae-bum Park, Dan-bi Park, Ji-hoon Lee, Su-jeong Yang, Ji-eun Lee, Jin-Kyung Park, Jeung-Soo Huh and Jeong-Ok Lim
Appl. Sci. 2022, 12(22), 11599; https://doi.org/10.3390/app122211599 - 15 Nov 2022
Cited by 5 | Viewed by 2253
Abstract
In this study, graphene oxide (GO) was coated on the surface of a large-area polystyrene film using spray coating. To analyze the possibility of developing a large-area cell culture vessel from this material, the mechanical properties of the coated surface as well as [...] Read more.
In this study, graphene oxide (GO) was coated on the surface of a large-area polystyrene film using spray coating. To analyze the possibility of developing a large-area cell culture vessel from this material, the mechanical properties of the coated surface as well as the cell compatibility and cell proliferation in the vessel were evaluated. Step measurements confirmed a curve of 100 nm or larger on the cell culture vessel surface. The surface was composed of GO (as determined from Raman spectroscopy) and its measured transmittance was ~90% or higher. The coated surface was rendered hydrophilic with an increase in surface energy. Although the cells hardly grew on the general polystyrene film, they attached and proliferated on the polystyrene film coated with GO. Zero cytotoxicity was reported, particularly in the sample that was spray-coated three times at 93.75 mm/s. Note that the cell viability was 1.43 times higher than that in the conventional cell culture vessel. Economic and efficient large-area cell culture vessels can be developed if the GO coating establishes an appropriate surface roughness and surface energy. Full article
(This article belongs to the Special Issue Bio-Materials in Regenerative Medicine)
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