Extracellular Chaperones and Related miRNA as Diagnostic Tools of Chronic Diseases: From Cell Differentiation to Molecular Diagnostics
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 453
Special Issue Editors
Interests: cell differentiation; tissue homeostasis; organ remodeling
Special Issues, Collections and Topics in MDPI journals
2. Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy
Interests: molecular chaperones; chaperonopathies; chaperonotherapy; gut microbiota; gut–brain axis; extracellular vesicles; outer membrane vesicles (OMVs); tissue homeostasis
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs) are 50-1000 nm membrane-bound particles released from eukaryotic and prokaryotic cells which are involved in communication between cells near and far from the cell of origin, and this interaction has an impact on the functions of the target cell. They transfer various molecules, such as RNAs, miRNAs and proteins, including chaperones such as heat shock proteins (HSPs). In cellular homeostasis, chaperones and related miRNAs have been shown to be involved in cell differentiation, tissue homeostasis and organ remodeling. Thus, these molecules participate in many cellular processes under both physiological and pathological conditions, such as the regulation of immune responses, cell proliferation, apoptosis, carcinogenesis, angiogenesis and metastasis. The aim of this Special Issue is to collect a series of papers which present scientific evidence that extracellular chaperones and their related miRNA could be potential biormarkers of chronic disease, with a high potential of benefits for regenerative medicine, probably being the most effective way to deliver therapeutic molecules into target cells. We also wish to emphasise the importance of fully understanding the role of extracellular HSPs released from EVs and related miRNAs and encourage further research in this field to use them as early biomarkers and therapeutic targets.
Dr. Francesca Rappa
Dr. Letizia Paladino
Guest Editors
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Keywords
- extracellular vesicles (EVs)
- exosomes
- molecular chaperones
- miRNA
- heat shock proteins (HSPs)
- chaperonotherapies
- regenerative medicine
- tissue homeostasis
- advanced diagnostics
- carcinogenesis
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