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Applied Sciences
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New Insights into Bioactive Compounds: At the Crossroads between Nutrition...
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New Insights into Bioactive Compounds: At the Crossroads between Nutrition and Pharmacology

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3935

Special Issue Editors

Prof. Dr. Min Jiang

E-Mail Website
Guest Editor
College of Pharmacy, Nankai University, 94 Weijin Rd, Nankai District, Tianjin 300071, China
Interests: activity of bioactive compounds; functional food development research; pharmacological and toxicological studies of natural products; chemical biology
Prof. Dr. Xiaoying Wang

E-Mail Website
Guest Editor
State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Yuquan Road, Nankai District, Tianjin 300193, China
Interests: cardiovascular pharmacology; gut microbiome and disease; translational medicine; system biology

Special Issue Information

Dear Colleagues,

Let Food Be Your Medicine, and Medicine Be Your Food. Nutrition focuses on the physiological effects and corresponding effects of nutrients on human health, as well as on the occurrence, development, and recovery of diseases, while pharmacology focuses on the treatment of diseases by active ingredients. As the modern medical model gradually changes from a simple medical service model to a comprehensive model integrating health care, prevention and medical treatment, nutrition and pharmacology are gradually melting into each other. How bioactive ingredients, especially those derived from functional foods or natural medicines, play a role in preventing or treating diseases is the intersection of nutrition and pharmacology. In order to promote the development and integration of nutrition and pharmacology and present the latest research results in this field, Applied Sciences plans to issue a special issue of "New Insights into Bioactive Compounds: At the Crossroads between Nutrition and Pharmacology", and researchers are welcome to contribute. We are currently inviting papers for the following themed article collections (including but not limited to):

  1. New methods and technologies for the research on nutritional activity of bioactive compounds;
  2. Efficacy research on bioactive compounds;
  3. Safety research on bioactive compounds;
  4. Research on bioactive compounds isolation, extraction and identification; 5 Functional food development research based on bioactive compounds.

Prof. Dr. Min Jiang
Prof. Dr. Xiaoying Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • functional food
  • nutrition
  • pharmacology
  • safety evaluation

Published Papers (2 papers)

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Research

13 pages, 3087 KiB  
Article
Anti-Inflammatory Activity of Chlorogenic Acid on Macrophages: A Simplified Simulation of Pharmacokinetics Following Ingestion Using a Windup Syringe Pump
by Lei Cao, Won Han, Sang Gil Lee and Joong Ho Shin
Appl. Sci. 2023, 13(1), 627; https://doi.org/10.3390/app13010627 - 03 Jan 2023
Cited by 5 | Viewed by 2189
Abstract
Cell-culture-based drug tests are usually performed in an instantaneous delivery manner. However, in vivo pharmacokinetic studies have shown a steady increase in the concentration of bioactive compounds in the plasma following oral administration, with the maximum concentration observed after several hours. Here, a [...] Read more.
Cell-culture-based drug tests are usually performed in an instantaneous delivery manner. However, in vivo pharmacokinetic studies have shown a steady increase in the concentration of bioactive compounds in the plasma following oral administration, with the maximum concentration observed after several hours. Here, a novel palm-sized syringe pump powered by the manual winding of a spring was utilized for sustained delivery of chlorogenic acid (CHA) to lipopolysaccharide (LPS)-challenged RAW 264.7 macrophages over 2 h. When delivered in a sustained manner and simulating the in vivo pharmacokinetics following oral administration, CHA showed a stronger inhibitory effect on LPS-induced expression of inducible nitric oxide synthase and the transcription and secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α. It also enhanced the mRNA expression of the gene encoding heme oxygenase 1. The suppression of phosphorylation of p38 but not the nuclear translocation of nuclear factor-κB was affected by the sustained delivery of CHA. High-performance liquid chromatography analysis indicated that the sustained delivery model showed a higher concentration of CHA in the conditioned medium two hours after starting the delivery. A stronger anti-inflammatory effect of CHA was observed upon sustained delivery to the cell medium, simulating an in vivo pharmacokinetic release profile following oral administration. Full article
(This article belongs to the Special Issue New Insights into Bioactive Compounds: At the Crossroads between Nutrition and Pharmacology)
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10 pages, 637 KiB  
Article
Nutrition for Increased Adaptive Capacity, Better Sports Performance and Improved Quality of Life
by Nikolay Yurievich Latkov, Diana Tokhtarovna Dzhatdoeva, Boisjoni Tokhiriyon, Valentina Lapina, Valeriy Mikhailovich Poznyakovsky, Yusup Mohambekovich Dzhabrailov, Olga Anatolyevna Sorokopudova, Elena Valeryevna Karanina, Asya Valentinovna Kotandzhyan and Victoria Vyacheslavovna Kalitskaya
Appl. Sci. 2022, 12(24), 12681; https://doi.org/10.3390/app122412681 - 10 Dec 2022
Viewed by 1196
Abstract
The present study discusses foods for professional athletes since sports nutrition is the foundation of effective performance. A dietary supplement complex designed for ski orienteers, swimmers, road cyclists, and biathletes is described. The composition of the dietary supplement complex with directed influence on [...] Read more.
The present study discusses foods for professional athletes since sports nutrition is the foundation of effective performance. A dietary supplement complex designed for ski orienteers, swimmers, road cyclists, and biathletes is described. The composition of the dietary supplement complex with directed influence on metabolic processes, intensity, and training load is given. All the ingredients for this complex are selected, taking into account their synergistic effect and safety. The manufacturing process, with its gentle process conditions like granulation at 40 °C, drying at 60 °C, and a relatively short manufacturing time, ensures the safety of biologically active ingredients and their functional properties. The manufacturing company is the International Organization for Standardization (ISO) certified and meets the General Manufacturing Practice (GMP) requirements. The clinical trials were undertaken to evaluate the efficacy of the dietary supplement complex. The findings indicate increased adaptation to training, enhanced recovery, and balanced emotional state. The benefits of adding the dietary supplement complex to eating plans of sportsmen are listed. Full article
(This article belongs to the Special Issue New Insights into Bioactive Compounds: At the Crossroads between Nutrition and Pharmacology)
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