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Occupational and Environmental Medicine: Exploring Practical Solutions

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 3125

Special Issue Editor


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Guest Editor

Special Issue Information

Dear Colleagues,

Occupational and environmental medicine plays a critical role in safeguarding the health and well-being of workers and communities. This proposed Special Issue aims to highlight the practical applications of scientific research in addressing challenges related to occupational health and environmental exposures.

The issue will feature a diverse range of topics, including novel approaches to hazard assessment, emerging environmental health risks, technological innovations for safety and health, interventions in challenging work environments, strategies for chronic disease prevention, and the intersection of policy and practice.

The contributions to this Special Issue will offer insights into real-world solutions, bridging the gap between scientific knowledge and its implementation in occupational and environmental settings. Through collaborative efforts, we aim to advance the field and promote healthier, safer workplaces and communities worldwide.

The proposed topics for this Special Issue include, but are not limited to, the following: 

  • Novel approaches to occupational hazard assessment;
  • Emerging environmental health risks in the workplace;
  • Technological innovations for occupational safety and health;
  • Occupational health interventions in challenging work environments;
  • Environmental exposures and chronic disease prevention;
  • Occupational health policy and regulation: bridging science and practice.

Dr. Caterina Ledda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • occupational hazard assessment
  • emerging environmental health risks
  • occupational safety and health
  • occupational health interventions
  • environmental exposures
  • chronic disease prevention
  • occupational health policy and regulation

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Published Papers (2 papers)

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Research

17 pages, 2151 KiB  
Article
In Vitro Antioxidant Effects of Coenzyme Q10 on Cellular Metabolism in Aged Mesenchymal Stem Cells
by Alexandra Ivan, Alexandra Teodora Lukinich-Gruia, Iustina-Mirabela Cristea, Maria-Alexandra Pricop, Crenguta Livia Calma, Andreea Paunescu, Calin Adrian Tatu, Atena Galuscan and Virgil Paunescu
Appl. Sci. 2025, 15(5), 2783; https://doi.org/10.3390/app15052783 - 5 Mar 2025
Viewed by 823
Abstract
(1) Background: this study investigates the short-term effects of coenzyme Q10 (CoQ10) on mitochondrial respiration, fatty acid metabolism, oxidative stress gene expression, and sirtuin activity in young (passage 5, P5) and aged (passage 16, P16) mesenchymal stem cells (MSCs). (2) Methods: Mitochondrial respiration [...] Read more.
(1) Background: this study investigates the short-term effects of coenzyme Q10 (CoQ10) on mitochondrial respiration, fatty acid metabolism, oxidative stress gene expression, and sirtuin activity in young (passage 5, P5) and aged (passage 16, P16) mesenchymal stem cells (MSCs). (2) Methods: Mitochondrial respiration was assessed by measuring oxygen consumption after 24 h of treatment. Gas chromatography–mass spectrometry (GC-MS) analysis assessed cellular fatty acid methyl ester profiles. Quantitative polymerase chain reaction (qPCR) demonstrated the passage-dependent expression of oxidative stress-related genes and sirtuins in response to CoQ10 treatment. (3) Results: CoQ10 enhanced basal respiration and spare respiratory capacity (SRC), particularly in older senescent cells. CoQ10 improved basal respiration and ATP-linked oxygen consumption in young MSCs and partially restored these functions in aged MSCs. Moreover, CoQ10 increased saturated fatty acids, particularly in young cells, and decreased monounsaturated fatty acids in aged cells. qPCR analysis revealed passage-dependent modifications in oxidative stress-related genes and sirtuin expression; CoQ10 exposure significantly influenced SIRT1 and SIRT3 activity, leading to an increase in PPARγ and CAT expression. (4) Conclusions: these results highlight CoQ10’s potential to alleviate mitochondrial dysfunction and metabolic shifts associated with cellular aging, underscoring its therapeutic value for age-related mitochondrial and metabolic disorders. Full article
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30 pages, 1127 KiB  
Article
ChatGPT-4 vs. Google Bard: Which Chatbot Better Understands the Italian Legislative Framework for Worker Health and Safety?
by Martina Padovan, Alessandro Palla, Riccardo Marino, Francesco Porciatti, Bianca Cosci, Francesco Carlucci, Gianluca Nerli, Armando Petillo, Gabriele Necciari, Letizia Dell’Amico, Vincenzo Carmelo Lucisano, Sergio Scarinci and Rudy Foddis
Appl. Sci. 2025, 15(3), 1508; https://doi.org/10.3390/app15031508 - 1 Feb 2025
Viewed by 1585
Abstract
Large language models, such as ChatGPT-4 and Google Bard, have demonstrated potential in healthcare. This study explores their utility in occupational medicine, a field where decisions rely on compliance with specific workplace health and safety regulations. A dataset of questions encompassing key occupational [...] Read more.
Large language models, such as ChatGPT-4 and Google Bard, have demonstrated potential in healthcare. This study explores their utility in occupational medicine, a field where decisions rely on compliance with specific workplace health and safety regulations. A dataset of questions encompassing key occupational health topics derived from the Italian Legislative Decree 81/08, which governs workplace health and safety, was utilized. Responses from ChatGPT-4 with contextual information (ChatGPT-4+context) and Google Bard were evaluated for accuracy and completeness, with error categorization used to identify common issues. Subcategories of the topics of the regulations were analyzed as well. In total, 433 questions were included in our analysis. ChatGPT-4+context surpasses Bard in terms of accuracy and completeness in responses, with a lower error rate in the categories analyzed, except for the percentage of missed responses. In the subcategories analyzed, Bard is superior to ChatGPT-4+context only in the areas of the manual handling of loads and physical hazards. ChatGPT-4+context outperformed Bard in providing answers about Italian regulations on health and safety at work. This study highlights the potential and limitations of large language models as decision-support tools in occupational medicine and underscores the importance of regulatory context in enhancing their reliability. Full article
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