Feature Review for Applied Biosciences

A special issue of Applied Biosciences (ISSN 2813-0464).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 520

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1. Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, QLD 4072, Australia
2. ARC Centre of Excellence for Plant Success in Nature and Agriculture, University of Queensland, Brisbane, QLD 4072, Australia
Interests: genomics; transcriptomics; plant adaptation; wild crop relatives; output traits
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Dear Colleagues,

This Special Issue will feature reviews of key areas and emerging areas of science that are likely to deliver critical technologies. Advances in biological research are generating new options for application in a wide range of areas. These applications may include novel diagnostic tools and technologies that help manage health, the environment, and food and energy production. This Special Issue will be a collection of critical reviews of important areas of bioscience that will be key references for researchers.

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Keywords

  • reviews
  • biosciences
  • diagnostics
  • biotechnology
  • bioengineering

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Published Papers (1 paper)

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Review

13 pages, 421 KiB  
Review
Urinary Markers for Prostate Cancer: State of the Art
by Carlo Giorgio Costi, Serena Sartori, Riccardo Danuso, Andrea Piasentin, Paolo Umari and Giovanni Liguori
Appl. Biosci. 2025, 4(2), 24; https://doi.org/10.3390/applbiosci4020024 - 8 May 2025
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Abstract
Prostate cancer (PCa) is one of the most common malignancies in men, where early and accurate detection is crucial. While PSA testing has been the diagnostic standard, its limited specificity leads to unnecessary biopsies and missed significant cancers. Urinary biomarkers such as PCA3 [...] Read more.
Prostate cancer (PCa) is one of the most common malignancies in men, where early and accurate detection is crucial. While PSA testing has been the diagnostic standard, its limited specificity leads to unnecessary biopsies and missed significant cancers. Urinary biomarkers such as PCA3 and TMPRSS2-ERG and multi-marker assays (MyProstateScore, SelectMDx, and ExoDx) offer a promising alternative. This narrative review examines their diagnostic performance and clinical utility with the aim of understanding whether they can be integrated with the established tests and exams already in use. A literature search of PubMed, Scopus, and Medline identified some relevant recent studies (2010–2025). The findings show that PCA3 and TMPRSS2-ERG improve specificity over PSA, while multi-marker tests enhance risk stratification and reduce unnecessary procedures. MPS integrates urinary biomarkers with PSA, achieving over 95% sensitivity and negative predictive value for clinically significant cancers. SelectMDx demonstrates ~90% negative predictive value, and ExoDx assesses urinary exosomes to predict aggressive disease. Despite their advantages, challenges persist, including variability in performance, cost, and accessibility. Urinary biomarkers represent a major step toward more precise, less invasive diagnostics, with future research needed to optimize clinical integration and cost-effectiveness. Full article
(This article belongs to the Special Issue Feature Review for Applied Biosciences)
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