Current Efforts for Development of Novel Therapeutics to Combat Antibiotic Resistance

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 6646

Special Issue Editor


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Guest Editor
School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Interests: antimicrobial therapeutics; cationic antimicrobial peptides; drug-resistant bacteria; antibiotics

Special Issue Information

Dear Colleagues,

While most public health efforts have been directed towards the COVID-19 pandemic in the last two years, it is imperative that we continue to address other public health challenges. Among these challenges is the crisis created by antibiotic resistance, which requires a comprehensive multipronged approach. An important consideration is the development of therapeutics with novel mechanisms. It is in this context that we are presenting this Special Issue of Antibiotics to review the progress on novel approaches to antimicrobial therapy and the prospects for new therapeutics for overcoming resistance to traditional antibiotics.

Prof. Dr. Berthony Deslouches
Guest Editor

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Published Papers (1 paper)

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Review

15 pages, 630 KiB  
Review
Stability of Antimicrobials in Elastomeric Pumps: A Systematic Review
by Beatriz Fernández-Rubio, Paula del Valle-Moreno, Laura Herrera-Hidalgo, Alicia Gutiérrez-Valencia, Rafael Luque-Márquez, Luis E. López-Cortés, José María Gutiérrez-Urbón, Sonia Luque-Pardos, Aurora Fernández-Polo and María V. Gil-Navarro
Antibiotics 2022, 11(1), 45; https://doi.org/10.3390/antibiotics11010045 - 30 Dec 2021
Cited by 22 | Viewed by 6153
Abstract
Outpatient parenteral antimicrobial therapy (OPAThttp) programs have become an important healthcare tool around the world. Portable elastomeric infusion pumps are functional devices for ambulatory delivery of antimicrobial drugs, and their stability is an essential point to guarantee an appropriate infusion administration. We conducted [...] Read more.
Outpatient parenteral antimicrobial therapy (OPAThttp) programs have become an important healthcare tool around the world. Portable elastomeric infusion pumps are functional devices for ambulatory delivery of antimicrobial drugs, and their stability is an essential point to guarantee an appropriate infusion administration. We conducted a systematic review to provide a synthesis and a critical evaluation of the current evidence regarding antimicrobial stability in elastomeric pumps. Data sources were PubMed, EMBASE, and Web of Sciences. The review protocol was registered on the Center for Open Science, and it was carried out following the PRISMA guidelines. Studies were eligible if the aim was the evaluation of the physicochemical stability of an antimicrobial agent stored in an elastomeric device. Of the 613 papers identified, 33 met the inclusion criteria. The most studied group of antimicrobials was penicillins, followed by cephalosporins and carbapenems. In general, the stability results of the antimicrobials that have been studied in more than one article agree with each other, with the exception of ampicillin, flucloxacillin, and ceftazidime. The antibiotics that displayed a longer stability were glycopeptides and clindamycin. Regarding the stability of antifungals and antivirals, only caspofungin, voriconazole, and ganciclovir have been investigated. The information provided in this article should be considered in patient treatments within the OPAT setting. Further stability studies are needed to confirm the appropriate use of the antimicrobials included in this program to ensure optimal patient outcomes. Full article
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