Combating the Ever-Increasing Issue of Antimicrobial Resistance with a One Health Strategy in Environment and Medical Systems

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 10785

Special Issue Editors


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Guest Editor
Microbiome Research Centre, St George and Sutherland Clinical School, Department of Medicine, University of New South Wales, 18 High St, Kensington, Sydney, NSW 2052, Australia
Interests: microbiome; antimicrobial resistance; metagenomic next generation sequencing (mNGS); bioinformatics
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Guest Editor
School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, China
Interests: metagenomics; antimicrobial resistance; microbial ecology; drinking water; biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The emerging antimicrobial resistance (AMR) poses a great threat to public health. The top ten global health threats proposed by the World Health Organization (WHO) in 2019 include the ever-increasing AMR issue. Due to the wide application of antibiotics in recent decades, antimicrobial resistance genes (ARGs) have been transmitted, disseminated, and cycled among various environments and human medical systems, resulting in a one-health issue. A one-health combating strategy is urgently needed. The AMR of clinical important pathogenic species and environment dissemination have been extensively investigated; however, a holistic view of the distribution and dissemination of ARGs in all microorganisms is still lacking. Thanks to the development and maturation of clinical and environmental metagenomic next/third-generation sequencing, in combination with culturing and imaging, the community is heading towards a better understanding of the issue and the development of mitigation strategies.

This Special Issue will include topics related to 1) ARG dissemination in public health related system; 2) ARGs in emerging pathogens for various diseases; 3) Mobility of antimicrobial resistance genes in mobile genetic elements; 4) Novel treatment of drug-resistance bacteria by phage therapy or other antimicrobial strategies

Dr. Xiaotao Jiang
Prof. Dr. Liping Ma
Guest Editors

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Keywords

  • Antimicrobial resistance
  • Mobile genetic elements (MGEs)
  • Phage therapy
  • One health issue
  • Environmental dissemination of ARGs

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Published Papers (1 paper)

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Review

23 pages, 1758 KiB  
Review
Endolysin, a Promising Solution against Antimicrobial Resistance
by Mujeeb ur Rahman, Weixiao Wang, Qingqing Sun, Junaid Ali Shah, Chao Li, Yanmei Sun, Yuanrui Li, Bailing Zhang, Wei Chen and Shiwei Wang
Antibiotics 2021, 10(11), 1277; https://doi.org/10.3390/antibiotics10111277 - 20 Oct 2021
Cited by 96 | Viewed by 9983
Abstract
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases. The advent of pandrug-resistant bacteria makes most, if not all, available antibiotics invalid. Meanwhile, the pipeline of novel antibiotics development stagnates, [...] Read more.
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases. The advent of pandrug-resistant bacteria makes most, if not all, available antibiotics invalid. Meanwhile, the pipeline of novel antibiotics development stagnates, which prompts scientists and pharmacists to develop unconventional antimicrobials. Bacteriophage-derived endolysins are cell wall hydrolases which could hydrolyze the peptidoglycan layer from within and outside of bacterial pathogens. With high specificity, rapid action, high efficiency, and low risk of resistance development, endolysins are believed to be among the best alternative therapeutic agents to treat multidrug resistant (MDR) bacteria. As of now, endolysins have been applied to diverse aspects. In this review, we comprehensively introduce the structures and activities of endolysins and summarize the latest application progress of recombinant endolysins in the fields of medical treatment, pathogen diagnosis, food safety, and agriculture. Full article
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