Antibiotics and Antimicrobial Resistance in Aquaculture: Alternative and Complementary Treatment Methods

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 30 April 2025 | Viewed by 774

Special Issue Editor


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Guest Editor
Laboratorio de Biotecnología, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Macul, Santiago 7810000, Chile
Interests: diet-microbiota-host interaction; nutrition; aditives; probiotics; antibiotics; health; sustainable aquaculture
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Special Issue Information

Dear Colleagues,

This Special Issue aims at addressing the pressing issue of antibiotic use and antimicrobial resistance (AMR) in aquaculture by exploring alternative and complementary treatment methods. The use of antibiotics in aquaculture has raised concerns about the development and spread of AMR, posing risks to both animal and human health. As editors with expertise in antibiotics and AMR in aquaculture, we recognize the importance of finding sustainable solutions to reduce antibiotic usage while maintaining effective disease management strategies.  

This Special Issue will provide a platform for researchers to share innovative approaches and methods aimed at mitigating the reliance on antibiotics in aquaculture. We welcome contributions that cover a wide range of topics, including but not limited to the following: 

  • Alternative antimicrobial agents (e.g., probiotics, prebiotics, phage therapy);
  • Immunostimulants and vaccination strategies;
  • Biosecurity measures and management practices to prevent disease outbreaks;
  • Nutritional interventions to enhance immune function and disease resistance;
  • Integrated multitrophic aquaculture systems;
  • The wide spread of AMR;
  • Regulatory frameworks and policy recommendations to promote responsible antibiotic use in aquaculture.

Dr. Jaime Romero
Guest Editor

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • antibiotics
  • antimicrobial resistance
  • alternatives
  • aquaculture
  • probiotics
  • phage therapy

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Published Papers (1 paper)

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Research

12 pages, 1705 KiB  
Communication
Unveiling Hidden Allies: In Silico Discovery of Prophages in Tenacibaculum Species
by Carolina Ramírez and Jaime Romero
Antibiotics 2024, 13(12), 1184; https://doi.org/10.3390/antibiotics13121184 - 5 Dec 2024
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Abstract
Tenacibaculosis, caused by Tenacibaculum species, is a significant disease in aquaculture, leading to high mortality and economic losses. Antibiotic treatment raises concerns about resistance, making phage therapy an interesting alternative. Analyzing phage traces in Tenacibaculum genomes is crucial for developing these bacteriophage-based strategies. [...] Read more.
Tenacibaculosis, caused by Tenacibaculum species, is a significant disease in aquaculture, leading to high mortality and economic losses. Antibiotic treatment raises concerns about resistance, making phage therapy an interesting alternative. Analyzing phage traces in Tenacibaculum genomes is crucial for developing these bacteriophage-based strategies. Methods: We assessed the presence of prophages in 212 Tenacibaculum genomes/assemblies available in the NCBI repository, comprising several species and global locations, using the PHASTEST program. Then, we focused on those regions classified as intact, evaluating the most common phages found using VICTOR. The protein of interest discovered in the prophages was evaluated using the ProtParam, DeepTMHMM, InterPro, and Phyre2 tools. In addition, we evaluated the presence of antiphage defense systems in those genomes with intact prophages using the DefenseFinder tool. Results: We identified 25 phage elements in 24 out of the 212 Tenacibaculum genomes/assemblies analyzed, with 11% of the assemblies containing phage elements. These were concentrated in T. maritimum and T. mesophilum, which harbored 10 and 7 prophage regions, respectively. Of the identified elements, six were classified as intact, including four in T. maritimum, with the most common phages belonging to the Pippivirus and Siphoviridae families. Bioinformatic analysis showed that the putative endolysin is a stable protein of 432 amino acids and 49.8 kDa, with three transmembrane helices and a CHAP domain, structurally similar to the CHAP lytic domain of S. aureus bacteriophage K. Conclusions: Key prophage elements in Tenacibaculum, especially in T. maritimum, show promise for phage therapy against tenacibaculosis, supporting sustainable, antibiotic-free treatments in aquaculture. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. An Alternative Treatment and Microbiota in Rotifers

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