Therapeutic Drug Monitoring of Antimicrobials
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics of Drugs".
Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 31433
Special Issue Editors
2. Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium
Interests: antibiotic therapy; dose optimization; pk/pd; antimicrobial tdm; augmented renal clearance; extracorporeal membrane oxygenation; critically ill
Special Issues, Collections and Topics in MDPI journals
Interests: perinatal pharmacology; neonatal clinical pharmacology; PBPK in special populations; newborn; infant; lactation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Several recent guidelines and position papers defined dose optimization as a priority for antimicrobial research in special patient populations such as critically ill patients. Therapeutic drug monitoring (TDM) is the most commonly recommended strategy to evaluate exposure and adapt dosing in critically ill patients. TDM can be used as such, or can be integrated in dosing nomograms or dosing software to optimize antimicrobial exposure, and ultimately, clinical outcome.
Whereas TDM was previously mainly performed out of concern for toxicity, there is currently a shift towards antimicrobial TDM for efficacy. For many antimicrobials, although a clear therapeutic range has been defined, the clinical benefit of TDM remains unclear. For some antimicrobials, such as most antivirals, the merit of TDM-based dose optimization is still to be defined. Several issues need to be addressed before broader antimicrobial TDM can be implemented in routine clinical ICU practice. Therefore, we encourage the submission of all papers that refine our understanding of antimicrobial TDM and its potential benefit in both adult and pediatric patients.
This Special Issue welcomes all types of submissions (original research papers, short communications, reviews, case reports and perspectives) related to antimicrobial TDM in special patient populations such as—but not limited to—critically ill patients, children, neonates, obese patients, hematological patients, patients with cystic fibrosis, etc.
Dr. Matthias Gijsen
Prof. Dr. Karel Allegaert
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Therapeutic Drug Monitoring
- Antimicrobial
- Dose Optimization
- Pharmacokinetics and Pharmacodynamics
- Antibiotic
- Personalised Dosing
- Critically Ill Patients
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