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Antibiotics
Special Issues
Polyphenols for Friendly Handling of Microbial Control
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Polyphenols for Friendly Handling of Microbial Control

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 13509

Special Issue Editors

Prof. Dr. Trinidad de Miguel

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Guest Editor
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Interests: antibiotics; phage; urinary tract infection; antimicrobial activity of natural extracts; polyphenols
Prof. Dr. Tomás González Villa

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Guest Editor
Department of Microbiology, Faculty of Pharmacy, University of Santiago de Compostela, 15706 Santiago de Compostela, Coruna, Spain
Interests: phage therapy; microbiology; microbial biotechnology; food microbiology; molecular microbiology; recombinant microorganisms; microbial bioactive compounds
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marta Martins

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Guest Editor
Department of Microbiology, Trinity College Dublin, Dublin, Ireland
Interests: alternative therapies; antimicrobial resistance; applied and environmental microbiology; bacterial pathogenicity; bacteriology and bacterial pathogenesis; biomedical sciences; clinical research, trials; diagnostics; drug discovery, profiling, targeting; host, pathogen interactions; immune system; immunomodulation; in vitro testing, trial methods; macrophage infection; multidrug resistance; tuberculosis

Special Issue Information

Dear Colleagues,

Phenolic compounds are a diverse group of natural substances composed of one or more hydroxyl groups attached to one or more aromatic or benzene rings. When featuring more than one phenolic unit, they are called polyphenols and their size ranges from elementary compounds to highly polymerized ones. Polyphenols represent one of the most numerous and widely distributed groups of secondary metabolites in the plant kingdom, being responsible for flower coloration among other functionalities.

In recent years, these molecules have gained interest due to their potential uses in clinics, as well as in the cosmetic and food industries. They have been reported to exhibit a wide range of physiological properties, such as being antimicrobial, antioxidant, antiallergenic, anti-inflammatory or cardioprotective.

The worrying increase in antimicrobial resistance generated by the extensive use of antimicrobial drugs has prompted the scientific community to turn to the study of natural substances. The promising reported antimicrobial properties of polyphenols make them good candidates to help to cope with the problem of antimicrobial resistances.

Prof. Dr. Trinidad de Miguel
Prof. Dr. Tomás González Villa
Prof. Dr. Marta Martins
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polyphenols
  • Plant extracts
  • Antimicrobial compounds
  • Antioxidant compounds
  • Antimicrobial resistances

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Published Papers (2 papers)

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Research

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17 pages, 3825 KiB  
Article
Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria
by Anna Ramata-Stunda, Zaiga Petriņa, Valda Valkovska, Mārtiņs Borodušķis, Līga Gibnere, Eleonora Gurkovska and Vizma Nikolajeva
Antibiotics 2022, 11(2), 160; https://doi.org/10.3390/antibiotics11020160 - 26 Jan 2022
Cited by 15 | Viewed by 6099
Abstract
Bacterial infections are a prevalent complication after primary viral respiratory infections and are associated with high morbidity and mortality. Antibiotics are widely used against bacterial respiratory pathogens; however, the rise in antibiotic-resistant strains urges us to search for new antimicrobial compounds, including ones [...] Read more.
Bacterial infections are a prevalent complication after primary viral respiratory infections and are associated with high morbidity and mortality. Antibiotics are widely used against bacterial respiratory pathogens; however, the rise in antibiotic-resistant strains urges us to search for new antimicrobial compounds, including ones that act synergistically with antibiotics. In this study, the minimal inhibitory (MIC) and minimal bactericidal (MBC) concentrations of a polyphenol-rich complex of green propolis, Tabebuia avellanedae bark, and Olea europaea leaf extracts against Staphylococcus aureus, Haemophilus influenzae, and Klebsiella pneumoniae were determined, followed by an analysis of the synergistic effect with clarithromycin, azithromycin, and amoxiclav (875/125 mg amoxicillin/clavulanic acid). A combination of extracts showed activity against all three bacterial strains, with MIC values ranging from 0.78 to 12.5 mg/mL and MBC values from 1.56 to 12.5 mg/mL. The extracts showed synergistic activity with azithromycin and clarithromycin against S. aureus, with clarithromycin against K. pneumoniae, and with all three tested antibiotics against H. influenzae. Synergy with clarithromycin was additionally evaluated in a time-kill assay where the synergistic effects against S. aureus and K. pneumoniae were seen within the first 6 h of incubation. The results show the potential of polyphenol-rich extracts in enhancing the efficacy of antibiotic therapy and indicate their potential to be used in the management of respiratory infections. Full article
(This article belongs to the Special Issue Polyphenols for Friendly Handling of Microbial Control)
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Review

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18 pages, 497 KiB  
Review
Antimicrobial Activity of Polyphenols and Natural Polyphenolic Extracts on Clinical Isolates
by Tamara Manso, Marta Lores and Trinidad de Miguel
Antibiotics 2022, 11(1), 46; https://doi.org/10.3390/antibiotics11010046 - 30 Dec 2021
Cited by 111 | Viewed by 6648
Abstract
Antibiotic resistance is a growing global problem that affects people, animals, the environment, and the economy. Many clinically relevant bacteria have become resistant to antibiotics, and this fact is emerging as one of the major threats to public health. The lack of new [...] Read more.
Antibiotic resistance is a growing global problem that affects people, animals, the environment, and the economy. Many clinically relevant bacteria have become resistant to antibiotics, and this fact is emerging as one of the major threats to public health. The lack of new antibiotics, which is due to their time-consuming and costly development, exacerbates the problem. Therefore, it is necessary to identify new antimicrobial agents to treat bacterial and fungal infections. Plant extracts, which are valuable sources of bioactive compounds, mainly polyphenols, play an important role as a new strategy to combat pathogenic microorganisms. There is an extensive body of supporting evidence for the potent antibacterial and antifungal activities of polyphenols. Furthermore, some polyphenols show a synergistic effect when combined with antibiotics and antifungals, suggesting a promising alternative for therapeutic strategies against antibiotic resistance. However, only a few articles are found when searching the antibacterial or antifungal activities of polyphenols employing clinical isolates. Hence, this review focuses on the antimicrobial activity of polyphenols and extracts rich in polyphenols on clinical isolates, organized according to the World Health Organization priority pathogens classification. Full article
(This article belongs to the Special Issue Polyphenols for Friendly Handling of Microbial Control)
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