Antimicrobial Pharmacokinetics and Pharmacodynamics in Children and in Adults
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2144
Special Issue Editors
Interests: Infections in pediatric intensive care and in critically ill pediatric patients; Bacterial and fungal infections in the immunocompromised host; PK/PD of anti-infectives
Interests: Bacterial and fungal infections in the immunocompromised host; infections in cystic fibrosis; PK/PD of anti-infectives
Special Issue Information
Dear Colleagues,
Although the antibiotic pipeline has been implemented by new molecules in recent years, therapeutic options for difficult-to-treat infections from germs may still be limited.
In particular, this is true in the pediatric field, where the indications for new drugs often arrive years later than what happens in the adult patient.
In common clinical practice, the plasma levels of anti-infective drugs are measured above all to evaluate their possible toxicity, as occurs for aminoglycosides or vancomycin, and more rarely therapeutic drug monitoring (TDM) is used to evaluate their efficacy, as during treatment with voriconazole.
The monitoring of plasma concentrations of antimicrobials when compared with the minimum inhibitory concentrations (MICs) for a given pathogen can represent a fundamental tool for the personalization of treatments and in the prevention of the onset of resistant strains.
The setting where TDM can certainly potentially play a crucial role is that of intensive care; in fact, the critically ill patient presents a series of conditions that can modify the PK/PD parameters of antibiotic therapies such as renal insufficiency, which increases the concentration of some molecules, or the hyperfiltration that reduces it; or therapeutic measures such as continuous renal replacement therapy rather than ExtraCorporeal Membrane Oxygenation.
Considering the complexity of the conditions that the clinician has to manage in real life and the fundamental importance that pharmacokinetics and pharmacodynamics play in precision medicine, studies that increase knowledge of this subject are increasingly needed.
Dr. Alessio Mesini
Prof. Dr. Elio Castagnola
Dr. Carolina Saffioti
Guest Editors
Manuscript Submission Information
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Keywords
- antimicrobial therapeutic drug monitoring
- antibiotic plasma levels
- antifungal plasma levels
- personalized treatment
- TDM in critical ill children
- TDM in ICU
- antimicrobial stewardship
