Pathophysiology, Diagnosis and Therapy of Sepsis

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2477

Special Issue Editors


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Guest Editor
Intensive Care Unit, Department of Anaesthesiology and Intensive Care, University Hospital of Modena, 41124 Modena, Italy
Interests: sepsis; immunity; multidrug resistant microorganisms; intensive care; shock
North Hospital, Aix Marseille University APHM, 13015 Marseille, France
Interests: infection; intensive care; sepsis; anti-infective agents
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Guest Editor
EA 7426 “Pathophysiology of Injury-Induced Immunosuppression” (Université Claude Bernard Lyon 1, Hospices Civils de Lyon, bioMérieux), Edouard Herriot Hospital, 69437, Lyon, France
Interests: intensive care; sepsis; septic shock

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Guest Editor
Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy
Interests: emergency medicine; critical care medicine; ICU; sepsis; mechanical ventilation; pharmacodynamics; airway management; cardiopulmonary resuscitation; hemodynamics; anesthesiology

Special Issue Information

Dear Colleagues,

Sepsis is a clinical syndrome that results from the dysregulated inflammatory response to infection that leads to organ dysfunction. The resulting losses to society in terms of financial burden, morbidity, and mortality are enormous.

Comprehensively defining "sepsis" has been the subject of constant development and refinement over the last decades. Although our understanding of sepsis origin, pathophysiology, and immunological mechanisms have progressed over the last three decades, our options for specific and successful therapeutic interventions remain limited. Only timely fluid resuscitation and early administration of broad-spectrum antibiotics have been shown to reduce mortality. A decisive factor is the time of correct diagnosis and the initiation of causal, supportive, and adjunctive measures. Moreover, the high heterogeneity of host response to infections and its changes with time require a personalized approach to patient management.

This Special Issue focuses on manuscripts related to the recent advancements in the knowledge of sepsis mechanisms, diagnostic protocols including new biomarkers, and new developing therapies for improving the prognosis of septic patients.

Dr. Massimo Girardis
Dr. Marc Leone
Dr. Anne-Claire Lukaszewicz
Dr. Gennaro De Pascale
Guest Editors

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Published Papers (1 paper)

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7 pages, 961 KiB  
Case Report
The First Lethal Infection by Oligella ureolytica: A Case Report and Review of the Literature
by Pierre Serandour, Chloé Plouzeau, Anthony Michaud, Lauranne Broutin, Julie Cremniter, Christophe Burucoa and Maxime Pichon
Antibiotics 2023, 12(9), 1470; https://doi.org/10.3390/antibiotics12091470 - 21 Sep 2023
Cited by 2 | Viewed by 1953
Abstract
Oligella ureolytica is a Gram-negative bacillus, a member of the Alcaligenaceae family, that had never previously been reported as lethal. Herein, a case of fatal infection caused by Oligella ureolytica in an elderly woman with suspected bladder cancer is reported. The species identification [...] Read more.
Oligella ureolytica is a Gram-negative bacillus, a member of the Alcaligenaceae family, that had never previously been reported as lethal. Herein, a case of fatal infection caused by Oligella ureolytica in an elderly woman with suspected bladder cancer is reported. The species identification was confirmed through Sanger sequencing of the bacterial 16S rRNA sequence and compared to published sequences for phylogenetic analysis. Initial antibiotic therapy with ceftriaxone and oxacillin was initiated but had to be switched due to resistance. Cefepime in combination with metronidazole was administered, unfortunately failing to prevent the patient’s death. Further studies are needed to explore additional factors influencing clinical outcomes in Oligella ureolytica infections. Full article
(This article belongs to the Special Issue Pathophysiology, Diagnosis and Therapy of Sepsis)
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