The Possible Role of Antibiotic-Modified Microbiome in the Development and Proliferation of Non-Communicable Diseases
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 387
Special Issue Editor
Interests: infectious diseases; tropical diseases; antibiotics; antibiotic consumption; microbiome; microbiome and diseases; antibiotic-consumption related non-contagious diseases
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Dear Colleagues，
The discovery and extensive utilization of antibiotics has greatly contributed to the considerable lengthening of human life expectancy. The addition of antibiotics to animal fodder was found to have a considerable growth-promoting effect, and hence extended the indications of antibiotics at a much higher level. The indiscriminate use of antibiotics quickly resulted in the emergence of poly-resistant pathogens and the extensive antibiotic pollution of the environment, particularly of the surface water through human and animal excreta. Along with extensive and ever-increasing antibiotic consumption/pollution, the pandemic-like spreading of certain non-contagious diseases like obesity, diabetes (type 1 and 2 diabetes mellitus—T1DM, T2DM), Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, autism, and different malignancies, among others, started unfolding, which has been referred to as a slow-moving disaster, without any appropriate explanation of the phenomenon. The parallel appearance of these “pandemics”, which appeared simultaneously with the extensive antibiotic consumption, might indicate some kind of association. As far as several publications have reported, the crucial role of altered gut flora in the development of metabolic disorders (diabetes, obesity, etc.) and neurodegenerative diseases etc., it might be suspected that antibiotics, acting through the modification of microbiome and the gut–brain axis, could influence the morbidity (prevalence) of these non-infectious diseases, serving as a unified explanation for the phenomenon.
Prof. Dr. Gábor Ternák
Guest Editor
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