Antifungal Resistance and Emerging Therapeutic Options
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1546
Special Issue Editor
Interests: antifungal resistance; fungal diseases; Candida; Aspergillus
Special Issue Information
Dear Colleagues,
The increased use of antifungal agents for the treatment of invasive fungal diseases results in antifungal resistance worldwide. Resistance to triazoles has been one of the major problems in invasive candidiasis and candidemia. The prevalence of fluconazole-resistance Candida tropicalis and other Candida species is increasing in some particular areas. Furthermore, outbreaks of Candida auris have been reported and hindered the infection control process.
In some countries azole-resistant Aspergillus was reported, particularly cryptic species, such as Aspergillus lentulus. It may be under-reported in other countries. Limited treatment for azole-resistant aspergillosis was associated with higher mortality.
Besides Candida and Aspergillus, other yeasts and molds may be intrinsically resistant to polyene or azole antifungal agents. Lometospora, Scedosporium, and dematiaceous fungi are among the difficult-to-treat fungal pathogens due to their resistant profiles.
Novel antifungal agents with new mechanisms are emerging. Antifungal targets are not only focused on membrane-associated ergosterol or cell-wall-associated beta-D-glucan, but also on the fungal enzymes used for various cellular functions. These are the new paradigm of antifungal therapy for infection caused by resistant fungi.
On the basis of this evidence, this Special Issue will publish papers focusing on fungal infection related to antifungal resistance and novel antifungal agents that can potentially be used to combat these resistant fungal pathogens.
Dr. Methee Chayakulkeeree
Guest Editor
Manuscript Submission Information
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Keywords
- antifungal resistance
- new antifungal
- azole-resistant
- invasive fungal diseases
- Candida
- Aspergillus
- mold infection
- resistance mechanism
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