Epidemiology, Impact and Mitigation of Antimicrobial Resistance in Veterinary Medicine, 3rd Edition

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 973

Special Issue Editor


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Guest Editor
Veterinary Medicine Research and Development, Regulatory Affairs, Zoetis, Mercuriusstraat 20, 1930 Zaventem, Belgium
Interests: antimicrobial resistance; veterinary pharmacology and toxicology; PK/PD; regulatory affairs
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Special Issue Information

Dear Colleagues,

The introduction of antimicrobial agents and anti-infective chemotherapy has been hugely beneficial for morbidity and mortality rates associated with bacterial infections, representing a clear paradigm shift in human and veterinary medicine.

Currently, we are experiencing the advent of a post-antibiotic era, where antimicrobial agents are progressively losing efficacy due to the seemingly unstoppable increase in antimicrobial resistance (AMR). Bacteria are becoming resistant to antimicrobials due to evolution and selection through chromosomal mutations and horizontal gene transfer. In the past few decades, we have witnessed the rise of (multi-)resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), carbapenem-resistant Enterobacteriaceae (CRE), and fluoroquinolone-resistant Pseudomonas aeruginosa.

The increasing and alarming levels of AMR are strongly associated with the use and consumption of antimicrobial agents. Treatment failure in veterinary medicine has negative repercussions for animal welfare and health, as well as the productivity of food-producing animals.

Animals, humans, and their shared environment are inextricably linked; this is known as the One Health concept. With respect to AMR, this implies that resistant bacteria and antimicrobial resistance genes can propagate between humans and animals via myriad complex interactions, unveiling AMR as a truly multifaceted threat.

This Special Issue constitutes a third volume on antimicrobial resistance in animals and aims to publish manuscripts covering topics such as:

  • The epidemiology and surveillance of AMR.
  • The mechanisms and evolution of resistance.
  • Clinical applications of existing and newer antimicrobials.
  • Approaches to improve the judicious use of antimicrobials.
  • Strategies to curb the emergence and dissemination of resistance in veterinary medicine.
  • One health impact of antimicrobial resistance and treatment.

The topics can apply to both companion animals and food-producing animals.

Dr. Robin Temmerman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • veterinary medicine
  • antibiotics
  • One Health
  • epidemiology

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Published Papers (1 paper)

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Research

14 pages, 937 KB  
Article
Shared Decision-Making in Veterinary Clinics: A Cross-Sectional Study Examining Effects on Appropriate Antibiotic Prescribing and Value-Driven Factors Influencing It
by Huiling Guo, Lay See Ong, Zoe Jane-Lara Hildon, Timothy Chua, Boon Han Teo and Angela Chow
Antibiotics 2025, 14(11), 1139; https://doi.org/10.3390/antibiotics14111139 - 10 Nov 2025
Viewed by 754
Abstract
Background: Shared decision-making (SDM) can improve appropriate antibiotic prescribing in human primary care clinics, but little is known about it in the veterinary setting. This study examines the association between SDM and antibiotic prescribing for cats and dogs in veterinary clinics, then determines [...] Read more.
Background: Shared decision-making (SDM) can improve appropriate antibiotic prescribing in human primary care clinics, but little is known about it in the veterinary setting. This study examines the association between SDM and antibiotic prescribing for cats and dogs in veterinary clinics, then determines the key factors influencing SDM through a value-driven approach. Methods: This cross-sectional study surveyed 41 veterinarians practicing in Singapore veterinary clinics. Appropriate antibiotic prescribing was defined as concordance with local antibiotic guidelines for companion animals, while an adapted SDM-Q-9-Doc scale measured SDM on antibiotic prescribing with pet owners. Questions were developed to measure constructs of the VALUE model and factor analysis was conducted to identify latent factors. Multivariable logistic and linear regressions were performed to assess the association between SDM and antibiotic prescribing, and determinants of SDM, respectively. Results: Antibiotics were most inappropriately prescribed for cats/dogs with ear infections (cocci observed) (63%), and periodontal disease (59%). Engaging owners in SDM (AOR 1.31; 95% CI 1.05, 1.62; p = 0.014) was positively associated with appropriate antibiotic prescribing for cats/dogs with periodontal disease. After adjusting for age, gender, clinic role and practice type, veterinarians with a higher overall VALUE score (β = 0.14; 95% CI 0.02, 0.26; p = 0.021) were more likely to engage in SDM with owners on antibiotic prescribing. Conclusions: SDM with pet owners improves appropriate antibiotic prescribing for cats and dogs, though effects vary by clinical scenario. Aligning AMR-related values between veterinary clinics and veterinarians to enable effective communication with pet owners can promote SDM and subsequently drive appropriate antibiotic prescribing for pet cats and dogs. Full article
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