Drug Residues Relative to Food Safety in Avian and Small Ruminants

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 4844

Special Issue Editor


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Guest Editor
College of Veterinary Medicine, University of California, Davis, CA, USA
Interests: drug residues relative to food safety (avian and small rumiant focus); antibiotic and antifungal therapeutic treatment regimes

Special Issue Information

Dear Colleagues,

Drug residue avoidance in animal products consumed by humans is a food safety focus worldwide. Continued access to antibiotics is critical to veterinary medicine. However, administration of these drugs to animals must be judicious in order to protect public health, with assurance that drug residues do not enter the human food chain.

For cattle, chickens, and swine there are numerous agency approved medications and mandated withdrawal times. In contrast, approved drugs for minor species, such as game birds and small ruminants, are limited. Therefore, drug administration to these minor species is often based on extrapolation from a related species or animal class.

The aim of this Special Issue is to publish original research papers or reviews concerning the use of antibiotics in birds and small ruminants to highlight the importance of pharmacokinetic and residue depletion studies. While live animal pharmacokinetic studies provide some insights into residue avoidance, tissue residue studies are the gold standard for accurately estimating withdrawal intervals. Other methods for estimating withdrawal interval recommendations, such as physiologically-based pharmacokinetic and non-linear mixed effect models, also play important roles in estimating withdrawal intervals.

I look forward to you sharing your recent findings through this Special Issue.

Prof. Dr. Lisa Tell
Guest Editor

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Keywords

  • medications
  • drug residues
  • tissues
  • pharmacokinetics
  • extra-label drug use
  • withdrawal intervals

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Published Papers (1 paper)

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Research

18 pages, 1986 KiB  
Article
Pharmacokinetic Parameters and Tissue Withdrawal Intervals for Sheep Administered Multiple Oral Doses of Meloxicam
by Sarah Depenbrock, Tara Urbano, Jessie Ziegler, Scott Wetzlich, Maaike O. Clapham and Lisa A. Tell
Animals 2021, 11(10), 2797; https://doi.org/10.3390/ani11102797 - 25 Sep 2021
Cited by 6 | Viewed by 4203
Abstract
Meloxicam is an anti-inflammatory drug used to treat pain and inflammation in ruminants including sheep, and pharmacokinetic studies are needed to protect the food supply from drug residues after use in food-producing animals. This study estimated plasma pharmacokinetic parameters and meat withdrawal intervals [...] Read more.
Meloxicam is an anti-inflammatory drug used to treat pain and inflammation in ruminants including sheep, and pharmacokinetic studies are needed to protect the food supply from drug residues after use in food-producing animals. This study estimated plasma pharmacokinetic parameters and meat withdrawal intervals (WDI) for market sheep after multiple daily oral doses of meloxicam. Single and multiple dose plasma pharmacokinetic studies, a multi-dose tissue depletion study, and a follow-up study to investigate if events prior to slaughter were associated with differences in plasma meloxicam concentrations, all using sample data collected after completion of dosing, were completed. Using regulatory agency methods for calculating withdrawal times, an estimated WDI of at least 10 d following the last dose is recommended for market lambs treated with 10 daily oral 1 mg/kg doses of meloxicam tablets suspended in water. The effect of events surrounding slaughter on plasma meloxicam concentrations in lambs is unknown but should be considered if plasma samples are obtained immediately prior to or during the slaughter process and used for pharmacokinetic investigations. Full article
(This article belongs to the Special Issue Drug Residues Relative to Food Safety in Avian and Small Ruminants)
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