Nutritional Interventions for Gut Health and Immunity in Livestock

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 783

Special Issue Editors

Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
Interests: gut microbiota; nutritional intervention; gut health; immunoregulation
Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
Interests: porcine digestive tract nutrition; carbohydrates and gut microbiota

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Nutritional Interventions for Gut Health and Immunity in Livestock," focuses on the pivotal role of nutrition in modulating gut microbiota, enhancing intestinal integrity, and bolstering immune responses in farm animals. Its scope encompasses interdisciplinary research in animal nutrition, gut microbiota dynamics, targeted nutritional interventions, gut health optimization, and immunoregulation strategies, including dietary supplements, probiotics, and feed formulations. The purpose is to advance knowledge on sustainable practices that improve livestock productivity, disease resistance, and welfare, ultimately supporting global food security and animal health.

This Issue will usefully supplement existing literature by bridging gaps between nutritional science and microbiology, integrating emerging data on host–microbe interactions and novel interventions amid challenges like antibiotic resistance and climate impacts. It aims to foster innovative, evidence-based approaches that extend beyond traditional studies, offering practical insights for researchers, veterinarians, and industry stakeholders to drive translational applications.

Dr. Lei Qiao
Dr. Siyu Wei
Guest Editors

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Keywords

  • animal nutrition
  • gut microbiota
  • nutritional intervention
  • gut health
  • immunoregulation

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Published Papers (1 paper)

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Research

23 pages, 1153 KB  
Article
Effects of Low-Energy Diets Supplemented with Lactobacillus reuteri Postbiotic on Growth Performance and Intestinal Health of Broiler Chickens
by Meng Peng, Huiqin Sun, Wenhui Shi, Miaomiao Liu, Shuangshuang Guo, Dan Yi, Binying Ding, Mengjun Wu, Xiudong Liao, Giuseppe Maiorano and Peng Li
Animals 2026, 16(7), 1011; https://doi.org/10.3390/ani16071011 - 25 Mar 2026
Viewed by 547
Abstract
This study aims to investigate the effects of low-energy diets (LE) supplemented with Lactobacillus reuteri postbiotics (HSY) on growth performance and intestinal health of broiler chickens. A total of 2400 one-day-old Ross 308 broiler chicks with an average initial body weight of 46.10 [...] Read more.
This study aims to investigate the effects of low-energy diets (LE) supplemented with Lactobacillus reuteri postbiotics (HSY) on growth performance and intestinal health of broiler chickens. A total of 2400 one-day-old Ross 308 broiler chicks with an average initial body weight of 46.10 ± 0.04 g were randomly assigned to a 2 × 2 factorial arrangement of treatments with 12 pens and 50 broiler chickens/pen for 39 days. Treatments were (1) CTR (basal diet), (2) LE (CTR-70 kcal ME/kg), (3) HSY (CTR + 0.5 kg/t HSY), and (4) LEHSY (LE + 0.5 kg/t HSY). LE increased the feed conversion ratio (FCR) of broilers (p = 0.03) without altering ADG, ADFI, and final BW. Supplementation with HSY significantly reduced the FCR of broilers (p = 0.001). HSY upregulated the activities of amylase and trypsin in jejunal digesta (p < 0.01). Furthermore, LE upregulated the expression of intestinal barrier-related genes such as Mucin-2, Claudin-1 and Occludin, and HSY upregulated the expression of Claudin-1 (p < 0.05). LE upregulated the expression of nutrient transport carriers such as SGLT1 and TRPV6 (p < 0.01), and HSY upregulated the expression of TRPV6 (p < 0.01). LE upregulated the expression of immune-related genes such as MHC-II (p = 0.002), and HSY upregulated the expression of IFN-γ, IL-10, and TGF-β (p < 0.05). LE and HSY both downregulated the expression of intestinal lipid metabolism-related genes like ACC, while upregulating the expression of FABP4 (p < 0.05). 16S rRNA sequencing showed that the HSY increased the Chao1 index of the jejunal microbiota and enriched beneficial bacteria such as Lactobacillus salivarius and Lactobacillus avium. LE and HSY both increased the concentrations of propionic and butyrate (p < 0.05). In summary, HSY can improve gut health and mitigate the negative impact of low-energy treatment on broiler growth performance by increasing the content of endogenous enzymes in the jejunum, improving gut microbiota structure, and increasing the content of short-chain fatty acids in the jejunum. Full article
(This article belongs to the Special Issue Nutritional Interventions for Gut Health and Immunity in Livestock)
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