Epidemiology of Antimicrobial Resistance: A One Health Approach

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 564

Editors


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Dipartimento di scienze biomediche chirurgiche ed odontoiatriche, Sezione One Health, Università degli studi di Milano, Via Pascal 36, Milano, Italy
Interests: statistics; epidemiology; microbiology; genomics; bioinformatics; infectious diseases; one health; public health

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Department of Biomedical, Surgical and Dental Sciences—One Health Unit, Università degli Studi di Milano, 20100 Milan, Italy
Interests: epidemiology; mastitis epidemiology and control; mammary gland immunity; antimicrobial resistance; One Health approach; public health
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Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) is a serious worldwide health concern caused by the overuse and abuse of antibiotics in several fields of application, which results in the growth of resistant microbes. AMR arises when microorganisms (including bacteria, fungi, viruses, and parasites) go through evolutionary processes that result in their resistance to antimicrobial drugs, such as antibiotics, which are frequently used as a treatment for those infections. To contain this ever-increasing hazard, effective and tempestive actions are required. Understanding AMR dynamics and dissemination requires broader epidemiological studies employing the most recent and sophisticated molecular tools. The One Health concept is closely related to such broader epidemiological studies that employ the so-called One Health approach as a collaborative effort of several disciplines that come together to create answers for human, animal, and environmental health rather than focusing just on only one of those fields. This Special Issue aims to gather original manuscripts addressing the diverse aspects of AMR in order to create a collection of articles that can facilitate the comprehension of such an intricate and complex topic. Research involving epidemiologic innovative approaches and technologies that consider antimicrobial resistance in a One Health context is desired, though studies involving the characterization of zoonotic pathogens’ dynamics, ecology and epidemiology are also welcome.

Dr. Valerio Massimo Sora
Prof. Dr. Alfonso Zecconi

Guest Editors

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Keywords

  • One Health
  • antimicrobial resistance
  • molecular biology
  • epidemiology

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Published Papers (1 paper)

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Research

20 pages, 7582 KB  
Article
Comparative Genomic Analysis of Bovine and Publicly Available Human Streptococcus agalactiae Genomes
by Gabriele Meroni, Valerio Massimo Sora, Alessio Soggiu, Piera Anna Martino, Giulia Laterza, Luciana Colombo, Francesca Zaghen, Luigi Bonizzi and Alfonso Zecconi
Animals 2026, 16(14), 2257; https://doi.org/10.3390/ani16142257 - 21 Jul 2026
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Abstract
Background/Objectives: Streptococcus agalactiae is one of the most significant pathogens causing infections in humans and mastitis in dairy cattle. This work focused on a comprehensive comparative pan-genomic analysis of bovine and human Group B Streptococcus to elucidate the genetic mechanisms underlying host adaptation [...] Read more.
Background/Objectives: Streptococcus agalactiae is one of the most significant pathogens causing infections in humans and mastitis in dairy cattle. This work focused on a comprehensive comparative pan-genomic analysis of bovine and human Group B Streptococcus to elucidate the genetic mechanisms underlying host adaptation and dissemination. Methods: Isolates of S. agalactiae from quarter milk samples from dairy herds in Lombardy (Italy), along with human strains, were considered. Whole genome sequencing was used to compare core and accessory genomes, assign sequence types, and find virulence and resistance factors. Results: 30 sequence types were detected, of which two (ST12 and ST23) in common between bovine and human. The allele frequencies for resistance determinants revealed elevated rates for tetM (59.8% overall, 66.5% in human clinical isolates), ermB (17.3% overall, 20.4% in human clinical isolates), and ant(6)la (8.9% overall, 12.8% in human clinical isolates). Bovine strains had accessory gene clusters linked to lactose metabolism and immunological evasion, whereas human isolates were concentrated in regions related to adhesion and antibiotic resistance. Conclusions: Comparative pan-genomics show that there is a small genetic overlap between bovine and human Group B Streptococcus populations. Full article
(This article belongs to the Special Issue Epidemiology of Antimicrobial Resistance: A One Health Approach)
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