Advances in Animal Chromosomal and Genomic Instability
A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Genetics and Genomics".
Deadline for manuscript submissions: closed (20 June 2025) | Viewed by 1079
Special Issue Editors
Interests: animal clinical cytogenetics; environmental cytogenetics; evolutionary animal cytognetics; molecular cytogenetics
Special Issues, Collections and Topics in MDPI journals
Interests: animal cytogenetics; molecular cytogenetics; evolutionary animal cytogenetics
Interests: clinical cytogenetics; molecular cytogenetics; bio-informatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mammalian chromosomes have largely been used as biological materials to identify the causes of congenital abnormalities, measure the impact of exposure to environmental mutagens, diagnose specific cancer types and assess their prognosis, and improve species taxonomy. Chromosome instability (CIN) is often linked to genomic instability (GIN) throughout genetic changes induced by mutagenic factors. Being a hallmark of cancer, CIN and GIN can serve as specific diagnostic, therapeutic, and prognostic biomarkers. It can also drive karyotype evolution and speciation.
Testing CIN can include the detection of (a) polyploidy and structural chromosome abnormalities; (b) chromosome breaks; (c) sister chromatid exchanges (SCEs); (d) micronuclei; (e) chromatin integrity; and (f) telomere changes. CIN can be studied using conventional techniques, FISH, the comet assay, and qPCR. GIN is essentially related to next-generation sequencing technology.
The aim of this Special Issue is to fill the gaps in the scientific knowledge on the processes associated with chromosome and genomic instability in animals. The present Special Issue is open to both original and review papers showing the origin and causes of CIN in animal cells. We invite manuscripts focusing on the clastogenic impact of exposure to mutagens, chromosome changes occurring during mitosis and/or meiosis, the significance of CIN in cancer, and its effects on species evolution.
Dr. Leopoldo Iannuzzi
Dr. Miluše Vozdova
Dr. Pietro Parma
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chromosome instability
- chromosome break
- ploidy
- sister chromatid exchange
- micronuclei
- chromatin integrity
- telomere
- cancer
- karyotype
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