Advances in Animal Chromosomal Instability

Dear Colleagues,

Mammalian chromosomes have largely been used as biological material to identify the causes of congenital abnormalities, measure the impact of exposure to environmental mutagens, diagnose specific cancer types and assess their prognosis, and improve species taxonomy. Chromosome instability (CIN) is often linked to genomic instability throughout genetic changes induced by mutagenic factors. Being a hallmark of cancer, CIN can serve as a specific diagnostic, therapeutic and prognostic biomarker. It can also drive karyotype evolution and speciation.

Testing CIN can include detection of: (a) polyploidy and structural chromosome abnormalities; (b) chromosome breaks; (c) sister chromatid exchanges (SCE); (d) micronuclei; (e) chromatin integrity; (f) telomere changes. CIN can be studied using conventional techniques, FISH, comet asay, qPCR and Next-Generation Sequencing technology.

The aim of the Special Issue is to fill the gaps in the scientific knowledge on the processes associated with chromosome instability in animals. The present Special Issue is open to both original and review papers showing the origin and causes of CIN in animal cells. We invite manuscripts focusing on the clastogenic impact of exposure to mutagens, chromosome changes occurring during mitosis and/or meiosis, significance of CIN in cancer, and its effects on species evolution.

Dr. Leopoldo Iannuzzi
Dr. Miluše Vozdova
Dr. Pietro Parma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• chromosome instability
• chromosome break
• ploidy
• sister chromatid exchange
• micronuclei
• chromatin integrity
• telomere
• cancer
• karyotype