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5.2
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Journals
Animals
Special Issues
New Perspectives in Porcine Epidemic Diarrhea Virus (PEDV)—Second Edition
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New Perspectives in Porcine Epidemic Diarrhea Virus (PEDV)—Second Edition

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Pigs".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 855

Special Issue Editors

Dr. Jianing Chen

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Guest Editor
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
Interests: cross-species transmission; pathogenicity of swine coronaviruses
Special Issues, Collections and Topics in MDPI journals
Dr. Jianbo Liu

E-Mail
Guest Editor
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China
Interests: porcine epidemic diarrhea virus; animal coronaviruses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Porcine epidemic diarrhea virus (PEDV) is a coronavirus of swine, a member of the Coronaviridae subfamily and the Nidovirales family. PEDV mainly targets the gastrointestinal tract and causes the destruction of villous enterocytes and villous atrophy, resulting in high morbidity and mortality in both newborn and suckling pigs, leading to serious economic losses in the swine industry. Thus, it is very important that we develop a more profound understanding of the virus.

The aim of this Special Issue is to collect the newest contributions in the field of PEDV research, providing new insights and addressing research on unresolved issues. Research areas may include, but are not limited to, the following: evolution, viral replication, virus–host interaction, pathogenesis and immunity, gene therapy, vaccines, and novel antiviral strategies. All researchers working in these fields are cordially invited to contribute original research papers or propose reviews to this Special Issue of Animals.

We look forward to receiving your contributions.

Dr. Jianing Chen
Dr. Jianbo Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • porcine epidemic diarrhea virus
  • viral replication
  • virus–host interaction
  • pathogenesis and immunity
  • novel antiviral strategies
  • molecular epidemiology

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Published Papers (1 paper)

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Research

16 pages, 10690 KB  
Article
Clade-Specific Recombination and Mutations Define the Emergence of Porcine Epidemic Diarrhea Virus S-INDEL Lineages
by Yang-Yang Li, Ke-Fan Chen, Chuan-Hao Fan, Hai-Xia Li, Hui-Qiang Zhen, Ye-Qing Zhu, Bin Wang, Yao-Wei Huang and Gairu Li
Animals 2025, 15(15), 2312; https://doi.org/10.3390/ani15152312 - 7 Aug 2025
Viewed by 436
Abstract
 Porcine epidemic diarrhea virus (PEDV) continues to circulate globally, causing substantial economic losses to the swine industry. Historically, PEDV strains are classified into the classical G1, epidemic G2, and S-INDEL genotypes. Among these genotypes, the highly virulent and prevalent G2 genotype has been [...] Read more.
 Porcine epidemic diarrhea virus (PEDV) continues to circulate globally, causing substantial economic losses to the swine industry. Historically, PEDV strains are classified into the classical G1, epidemic G2, and S-INDEL genotypes. Among these genotypes, the highly virulent and prevalent G2 genotype has been extensively studied. However, recent clinical outbreaks in China necessitate a reevaluation of the epidemiological and evolutionary dynamics of circulating strains. This study analyzed 37 newly sequenced S genes and public sequences to characterize the genetic variations of S-INDEL strains. Our analysis revealed that S-INDEL strains are endemic throughout China, with a phylogenetic analysis identifying two distinct clades: clade 1, comprising early endemic strains, and clade 2, representing a recently dominant, geographically restricted lineage in China. While inter-genotypic recombination has been documented, our findings also demonstrate that intra-genotypic and intra-clade recombination events contributed significantly to the emergence of clade 2, distinguishing its evolutionary pattern from clade 1. A comparative analysis identified 22 clade-specific amino acid changes, 11 of which occurred in the D0 domain. Notably, mutations at positively selected sites—113 and 114 within the D0 domain, a domain associated with pathogenicity—were specific to clade 2. A phylodynamic analysis indicated Germany as the epicenter of S-INDEL dispersal, with China acting as a sink population characterized by localized transmission networks and frequent recombination events. These results demonstrate that contemporary S-INDEL strains, specifically clade 2, exhibit unique recombination patterns and mutations potentially impacting virulence. Continuous surveillance is essential to assess the pathogenic potential of these evolving recombinant variants and the efficacy of vaccines against them.  Full article
(This article belongs to the Special Issue New Perspectives in Porcine Epidemic Diarrhea Virus (PEDV)—Second Edition)
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