Stem-Cell-Based Therapies in Veterinary Medicine—Current Status and Perspectives: Second Edition

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 599

Special Issue Editors


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Guest Editor
Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo 13635-900, Brazil
Interests: stem cells; animal models; acquired and genetic diseases; placenta
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo 13635-900, Brazil
Interests: biobanking; stem cell lineages; animal models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last three decades, abundant information and data from different stem cell lineages in domestic and wild animals have been gathered in the literature. However, new sources of tissue and different types of cells from different species must be strongly described in future articles. Biobanking and new protocols of stem cell lineages are encouraged, as is the their use in animal models of diseases, both acquired and genetics.

We are pleased to invite researchers from around the world to submit your manuscripts on stem-cell-based therapies sharing possible new therapies using stem cell lines from different species in preclinical trials. Strong data from stem cells animal collections must be published to open new avenues of alternatives therapies.

Cell line biobanking may help to produce information for future use in conservative perspectives or even to treat reproduction problems and may guarantee cell lines for cloning purposes.

Another important aspect is the search for alternative therapies that will help to improve the quality of life of animals and their owners.

We invite researchers to submit your articles to this Special Issue.

Dr. Carlos Eduardo Ambrósio
Dr. Daniele Santos Martins
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • stem cells
  • lineages
  • animal models
  • wild animals
  • domestic animals
  • biobanking

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Published Papers (1 paper)

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Research

19 pages, 7297 KiB  
Article
Repairing Qinling Giant Panda Skin Wounds Using Adipose Mesenchymal Stem Cell-Derived Extracellular Vesicles
by Suhua Gong, Hongyu Niu, Yanni Jia, Mengjie Liu, Xiaoyu Ren, Danhui Zhang, Jiena Shen, Chuangxue Yang, Yinghu Lei, Pengpeng Zhao and Pengfei Lin
Animals 2025, 15(9), 1270; https://doi.org/10.3390/ani15091270 (registering DOI) - 29 Apr 2025
Abstract
The Qinling giant panda has a high susceptibility to skin damage, which affects its survival. Although their healing efficacy in panda injuries remains unexplored, extracellular vesicles from adipose-derived mesenchymal stem cells (ADMSC-EVs) have shown promise in regenerative medicine. In this study, ADMSC-EVs were [...] Read more.
The Qinling giant panda has a high susceptibility to skin damage, which affects its survival. Although their healing efficacy in panda injuries remains unexplored, extracellular vesicles from adipose-derived mesenchymal stem cells (ADMSC-EVs) have shown promise in regenerative medicine. In this study, ADMSC-EVs were successfully obtained from Qinling giant pandas using ultracentrifugation, and proteomic techniques were used to analyze their composition and function. Primary skin fibroblasts from Qinling giant pandas were isolated and cultured to explore the effects of ADMSC-EVs on cell proliferation and migration. Additionally, a mouse model of skin injury was used to assess their wound healing effects. The ADMSC-EVs contained various substances, particularly proteins, with fifty unique proteins involved in transport, catabolism, and signal transduction identified. The application of ADMSC-EVs in a mouse model accelerated wound healing and promoted the regeneration of the epidermal and dermal layers. It facilitated the repair of skin appendages, including hair follicles and sebaceous glands. Additionally, ADMSC-EVs enhanced collagen deposition, stimulated angiogenesis, and reduced inflammation. Our findings confirm that ADMSC-EVs significantly improve skin healing, thus supporting the theoretical framework for the clinical use of giant panda extracellular vesicles and underscoring their potential for preserving the genetic resources of the Qinling giant panda. Full article
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