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Animals
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Diet-induced Obese Rodents
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Diet-induced Obese Rodents

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Physiology".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 3589

Special Issue Editor

Dr. Rajib Mukherjee

E-Mail Website
Guest Editor
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Interests: adipose tissue; diabetes; inflammation; macrophages; obesity; thermogenesis

Special Issue Information

Dear Colleagues,

I am excited to invite you to contribute to the Special Issue entitled “Diet-Induced Obese Rodents” for which I have the honor of editing for Animals.

Obesity has become a pandemic throughout the world. Obesity has emerged as a key contributing factor for multiple co-morbidities, including diabetes, cardiovascular diseases, NAFLD, and even cancers. These obesity-associated diseases confer a significant burden on the global health system. The current treatment strategies for obesity-associated diseases include strict dietary restrictions and lifestyle changes, which lack long-term efficacy. Therefore, we are in need of alternative pharmaceutical strategies that target adipose tissue metabolism and/or adipose tissue inflammation.

We are inviting the submission of original research articles that address unique approaches to combat obesity and its associated metabolic diseases, with special focus on novel pharmaceutical candidates (e.g., phytochemicals) and biological pathways. Additionally, papers may include new rodent models or dietary regimes.

Dr. Rajib Mukherjee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bio-active compounds
  • browning
  • diabetes
  • fatty liver
  • obesity
  • insulin signaling
  • thermogenesis

Published Papers (1 paper)

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Research

12 pages, 2205 KiB  
Article
Effect of Forskolin on Body Weight, Glucose Metabolism and Adipocyte Size of Diet-Induced Obesity in Mice
by Jing-Yi Chen, Shao-Yu Peng, Yeong-Hsiang Cheng, I-Ta Lee and Yu-Hsiang Yu
Animals 2021, 11(3), 645; https://doi.org/10.3390/ani11030645 - 1 Mar 2021
Cited by 5 | Viewed by 3187
Abstract
The purpose of this study was to investigate the effects of forskolin on body weight, glucose metabolism and fat cell diameter in high-fat diet-induced obese mice. Four-week-old male mice (C57BL/6) were randomly assigned to 1 of 3 treatment groups: a high-fat diet plus [...] Read more.
The purpose of this study was to investigate the effects of forskolin on body weight, glucose metabolism and fat cell diameter in high-fat diet-induced obese mice. Four-week-old male mice (C57BL/6) were randomly assigned to 1 of 3 treatment groups: a high-fat diet plus 5% dimethyl sulfoxide (vehicle), high-fat diet plus 2 mg/kg of forskolin (dissolved in 5% dimethyl sulfoxide) and high-fat diet plus 4 mg/kg of forskolin (dissolved in 5% dimethyl sulfoxide). Forskolin or dimethyl sulfoxide was administered intraperitoneally every two days. The results indicated that no significant difference was observed in the body weight, feed intake and serum lipid parameters among groups at 20 weeks of age. The blood glucose levels were significantly reduced in the groups treated with 2 mg/kg of forskolin before glucose tolerance test. Forskolin administration linearly decreased blood glucose levels of high-fat diet-fed mice at 90 min and total area under curve (AUC) after insulin tolerance test. The subcutaneous adipocyte diameter was significantly reduced in the groups treated with 2 mg/kg of forskolin. Forskolin administration linearly reduced the gonadal adipocyte diameter of high-fat diet-fed mice. Forskolin significantly reduced the differentiation of murine mesenchymal stem cells into adipocytes and this was accompanied by a decrease in intracellular triglyceride content and an increase in glycerol concentration in the culture medium. The subcutaneous adipocyte diameter, gonadal adipocyte diameter and total AUC of insulin tolerance test were moderately negatively correlated with the concentration of forskolin in the high-fat diet-induced obese model. These results demonstrate that forskolin can regulate glucose metabolism and reduce fat cell diameter of high-fat diet-fed mice and inhibit the adipocyte differentiation of murine mesenchymal stem cells. Full article
(This article belongs to the Special Issue Diet-induced Obese Rodents)
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