Feed Additives for Farm Animals: Gut Microbiome, Metabolism, Neuroendocrine Regulation, and Product Quality

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 193

Special Issue Editors


E-Mail Website
Guest Editor
Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Interests: anatomy; histology; gut; nutrition; endocrine; enteric nervous system

E-Mail Website
Guest Editor
Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Interests: Anatomy, histology, nutrition, GIT, radiology, veterinary

Special Issue Information

Dear Colleagues,

Feed additives are increasingly used to support the health and performance of farm animals, while also meeting expectations for efficient and responsible production. Many of these additives act first in the gut by shaping the microbial community and its metabolites, strengthening barrier function, and modulating immune responses. These local effects can translate into broader changes in nutrient use, stress resilience, and endocrine signals that connect the intestine with the nervous system and peripheral organs, ultimately influencing growth, robustness, and the quality of animal-derived products.

This Special Issue welcomes original research and reviews that clarify how feed additives, including probiotics, prebiotics, enzymes, phytogenics, organic acids, minerals, and emerging bioactives, affect the gut microbiome, host metabolism, neuroendocrine regulation, and product quality across farm species. We encourage studies that link mechanisms with practical outcomes, as well as works that identify biomarkers and support evidence-based use of additives in modern feeding programs.

We look forward to receiving your contributions.

Prof. Dr. Marcin Arciszewski
Dr. Cezary Osiak-Wicha
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiome
  • feed additives
  • intestinal health
  • host–microbe interactions
  • growth performance

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 55736 KB  
Article
Developmental Comparative Analysis of Enteroendocrine Hormone Immunoreactive Cells in the Abomasum and Small Intestine of Holstein–Friesian Bulls
by Ligia Janicka, Aleksandra Dajnowska, Katarzyna Woźniak, Cezary Osiak-Wicha, Katarzyna Kras, Iwona Łuszczewska-Sierakowska and Marcin B. Arciszewski
Animals 2026, 16(9), 1407; https://doi.org/10.3390/ani16091407 - 4 May 2026
Abstract
Within the complex regulatory network of the gastrointestinal tract, enteroendocrine cells play a fundamental role in coordinating digestive processes and maintaining metabolic balance. These cells produce a wide range of hormones that influence secretion, motility, and nutrient utilization, constituting an essential component of [...] Read more.
Within the complex regulatory network of the gastrointestinal tract, enteroendocrine cells play a fundamental role in coordinating digestive processes and maintaining metabolic balance. These cells produce a wide range of hormones that influence secretion, motility, and nutrient utilization, constituting an essential component of gastrointestinal physiology in ruminants. Despite the growing interest in the role of endocrine regulation in digestive system function, comprehensive studies evaluating enteroendocrine cell populations across different segments of the gastrointestinal tract in cattle remain limited. In particular, the organization of these cell populations in key digestive segments such as the abomasum and small intestine requires further investigation to better understand their functional significance. The aim of the present study was to provide a comparative characterization of selected enteroendocrine cell populations in the abomasum and small intestine of young and adult Holstein–Friesian bulls. Tissue samples collected from the abomasum, duodenum, jejunum, and ileum were subjected to histological and immunohistochemical analyses. Chromogranin A (CgA) was used as a general marker of enteroendocrine cells, and the number of cells immunoreactive to CgA as well as to gastrin, secretin, somatostatin (SOM), glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) was quantified in the examined segments of the gastrointestinal tract. All types of immunoreactive cells were counted using a standardized quantitative method based on the assessment of positively stained cells in randomly selected microscopic fields of histological sections. The results revealed clear differences in the number of enteroendocrine cells between the analyzed segments of the gastrointestinal tract as well as between the studied age groups. These findings indicate regional and age-related variation in enteroendocrine cell populations within the gastrointestinal tract and highlight their association with the functional organization of individual segments of the digestive system. Full article
Show Figures

Figure 1

Back to TopTop