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Med. Sci. Forum, 2026, IECBS-IECNS 2026

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Number of Papers: 2

8 pages, 550 KB

Open AccessProceeding Paper

Association Between Salivary Cortisol, Xerostomia, and Nitric Oxide Levels in Patients with Multiple Sclerosis: A Cross-Sectional Study

by Carlos Domínguez-Vargas, Jesús Eduardo García-Hernández, Emiliano Peña-Durán, Paloma Marylí Prado-López, Barbarita Sánchez-Peña, Miranda Citlali Pérez-Castellón, Dante Joel Márquez-González, Diana Margarita Robles-Loera, Samantha Jonnue Ramírez-Flores and Samuel Neri-Mendoza

Med. Sci. Forum 2026, 46(1), 1; https://doi.org/10.3390/msf2026046001 - 28 May 2026

Viewed by 331

Abstract

Multiple sclerosis (MS) is associated with neuroinflammation, autonomic dysfunction, and dysregulation of the hypothalamic–pituitary–adrenal axis. This cross-sectional study evaluated the relationship between salivary cortisol, xerostomia, nitric oxide (NO), and anxiety in 39 patients with MS. Cortisol levels were higher in patients with xerostomia and showed a weak-to-moderate positive correlation with xerostomia (ρ = 0.32; p = 0.047) and a moderate negative correlation with NO (ρ = −0.46; p = 0.0035). No association was found with anxiety or disease duration. These findings suggest a potential neuroendocrine–salivary pathway linking stress biomarkers with glandular dysfunction in MS. Full article

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9 pages, 461 KB

Open AccessProceeding Paper

Genome-Wide Variant Associations and Biological Pathways in Postherpetic Neuralgia

by Carlos Domínguez-Vargas, Jesús Eduardo García-Hernández, Emiliano Peña-Durán, Miranda Citlali Pérez-Castellón, Dante Joel Márquez-González, Diana Margarita Robles-Loera, Paloma Marylí Prado-López, Paola Fernanda Olmos-Suazo, Ramsés Emiliano Martínez-Hernández, Topacio Olivier Andrade-Romo and Gerardo Amaya-Tapia

Med. Sci. Forum 2026, 46(1), 2; https://doi.org/10.3390/msf2026046002 - 9 Jun 2026

Viewed by 72

Abstract

Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition that arises following varicella-zoster virus reactivation and represents a significant clinical burden. Despite known risk factors, the genetic basis of PHN remains poorly understood. This study aimed to identify genetic variants associated with PHN through the secondary analysis of GWAS summary data (GCST012124). One genome-wide significant locus (KIF1B) and several suggestive variants (PTPRZ1, PRKCE, CXCR4) were identified. These genes converge on pathways related to axonal transport, neuroinflammation, and nociceptive sensitization. Findings support a multifactorial genetic contribution to PHN and highlight potential targets for future research and therapeutic development. Full article

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