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Biology and Life Sciences Forum
Volume 43
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Biol. Life Sci. Forum, 2025, IECGE 2024

The 2nd International Electronic Conference on Genes

Online | 11–13 December 2024

Volume Editor:

Selvarangan Ponnazhagan, The University of Alabama at Birmingham, USA

Number of Papers: 3
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Cover Story (view full-size image): This volume collects the contributions from the 2nd International Electronic Conference on Genes held from the 11th to 13th December 2024. The conference served as a virtual space to present [...] Read more.
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19 pages, 234 KiB  
Conference Report
Abstracts of the 2nd International Electronic Conference on Genes
by Selvarangan Ponnazhagan
Biol. Life Sci. Forum 2025, 43(1), 1; https://doi.org/10.3390/blsf2025043001 - 28 Mar 2025
Viewed by 425
Abstract
The 2nd International Electronic Conference on Genes (IECGE2024) was organized by the MDPI open access journal Genes and held online from the 11th to 13th December 2024. This conference provided leading scientists with an online platform to share their latest research and engage [...] Read more.
The 2nd International Electronic Conference on Genes (IECGE2024) was organized by the MDPI open access journal Genes and held online from the 11th to 13th December 2024. This conference provided leading scientists with an online platform to share their latest research and engage in exciting discussions. The main topics and sessions of the conference were as follows: Non-coding RNAs in Health and Diseases; Genetic Diagnosis and Targeted Therapy in Cancer; Microbial Genetics and Genomics; Technologies and Resources for Genetics Research; Human Genomics and Genetic Diseases. This was an excellent opportunity for researchers and scientists to interact with each other, communicate with their colleagues, learn from each other, share ideas and results, help solve problems, and suggest alternative options for a better future. Full article
(This article belongs to the Proceedings of The 2nd International Electronic Conference on Genes)
5 pages, 641 KiB  
Proceeding Paper
mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer
by Saima Firdaus and Rafat Parveen
Biol. Life Sci. Forum 2025, 43(1), 2; https://doi.org/10.3390/blsf2025043002 - 31 Mar 2025
Viewed by 454
Abstract
Pancreatic cancer is one of the highly malignant cancers that have poor prognosis and limited treatment options. The development of targeted therapies is important for improving patient outcomes. In this study, we analyzed the datasets from the GEO database to identify potential mRNA [...] Read more.
Pancreatic cancer is one of the highly malignant cancers that have poor prognosis and limited treatment options. The development of targeted therapies is important for improving patient outcomes. In this study, we analyzed the datasets from the GEO database to identify potential mRNA biomarkers for pancreatic cancer. Differentially expressed gene (DEG) analysis was performed in R to identify genes that expressed differentially between tumor and normal samples. TFF1 and LAMC2 emerged as key candidate genes for pancreatic cancer among the identified DEGs. Additionally drugs approved by the FDA were repurposed as an inhibitor against key genes. These findings suggest that these genes play a significant role in pancreatic cancer progression and have the potential to serve as molecular elements for targeted therapies. Full article
(This article belongs to the Proceedings of The 2nd International Electronic Conference on Genes)
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8 pages, 907 KiB  
Proceeding Paper
Unsaturated 10H2DA Queen Bee Acid from Royal Jelly Modulates Epithelial-to-Mesenchymal Transition in SW-480 Colorectal Cancer Cells
by Milena M. Jovanović and Dragana S. Šeklić
Biol. Life Sci. Forum 2025, 43(1), 3; https://doi.org/10.3390/blsf2025043003 - 26 May 2025
Viewed by 266
Abstract
Cancer research largely focuses on epithelial-to-mesenchymal transition (EMT) as a critical mechanism required for the formation of metastases. This process involves the transformation of epithelial cells into mesenchymal cells by acquiring suppressed levels of anti-EMT and elevated expression of pro-EMT markers. Unsaturated fatty [...] Read more.
Cancer research largely focuses on epithelial-to-mesenchymal transition (EMT) as a critical mechanism required for the formation of metastases. This process involves the transformation of epithelial cells into mesenchymal cells by acquiring suppressed levels of anti-EMT and elevated expression of pro-EMT markers. Unsaturated fatty acid 10H2DA has not been investigated hitherto regarding its potential to target specific EMT markers in colorectal cancer (CRC). In our study, this substance showed successful upregulation of the expression of the anti-EMT marker E-cadherin and downregulation of the expression of pro-EMT markers SNAIL, N-cadherin, and Vimentin at the gene and protein levels. This prominent effect of 10H2DA in modulating the expression of specific and significant EMT markers in CRC should not be neglected in future studies regarding anticancer therapeutic approaches. Full article
(This article belongs to the Proceedings of The 2nd International Electronic Conference on Genes)
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